Protein Info for GFF47 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Phosphatidate cytidylyltransferase (EC 2.7.7.41)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 7 to 43 (37 residues), see Phobius details amino acids 56 to 73 (18 residues), see Phobius details amino acids 93 to 112 (20 residues), see Phobius details amino acids 120 to 141 (22 residues), see Phobius details amino acids 150 to 171 (22 residues), see Phobius details amino acids 192 to 210 (19 residues), see Phobius details amino acids 216 to 234 (19 residues), see Phobius details amino acids 264 to 282 (19 residues), see Phobius details PF01148: CTP_transf_1" amino acids 4 to 279 (276 residues), 239.9 bits, see alignment E=2.3e-75

Best Hits

Swiss-Prot: 95% identical to CDSA_SHIFL: Phosphatidate cytidylyltransferase (cdsA) from Shigella flexneri

KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 99% identity to ses:SARI_02780)

MetaCyc: 95% identical to CDP-diglyceride synthetase (Escherichia coli K-12 substr. MG1655)
Phosphatidate cytidylyltransferase. [EC: 2.7.7.41]; 2.7.7.41 [EC: 2.7.7.41]

Predicted SEED Role

"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF47 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
LLKYRLISAFVLIPAVIAALFLLPPVGFAIITLVVCMLAAWEWGQLSGFAARSQRVWLAV
LCGLLLALMLFLLPEYHHNIRQPLVEMSLWASLGWWVVALLLVLFYPGSAAIWRNSKTLR
LIFGLLTIVPFFWGMLALRAWHYDENHYSGAIWLLYVMILVWGADSGAYMFGKLFGKHKL
APKVSPGKTWQGFIGGLATAAVISWGYGMWANLNVAPVILLICSVVAALASVLGDLTESM
FKREAGIKDSGHLIPGHGGILDRIDSLTAAVPVFACLLLLVFRTL