Protein Info for GFF4688 in Variovorax sp. SCN45

Annotation: Cobalt/zinc/cadmium efflux RND transporter, outer membrane protein CzcC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 signal peptide" amino acids 1 to 21 (21 residues), see Phobius details PF02321: OEP" amino acids 59 to 231 (173 residues), 82.6 bits, see alignment E=1.6e-27 amino acids 263 to 437 (175 residues), 98.6 bits, see alignment E=2e-32

Best Hits

KEGG orthology group: None (inferred from 82% identity to vpe:Varpa_4080)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>GFF4688 Cobalt/zinc/cadmium efflux RND transporter, outer membrane protein CzcC (Variovorax sp. SCN45)
MRTLFVPLAVLAMAVPPAYSQQVTPSVPAAAGSSSSSPQASSRPATRTLEPAGPLTLRSA
VAMALRANPGLAAASREQDATEAAIVQAGAWPNPTLDAQLEDLRRDNRTTTLQLSQPIEL
GGKRAARVTAAERARDQAASALAGRRAEIRASTITAFFDVLTAQERLRLAQDSVGLAQTA
TRAATNRVAAGKVSPLEETRARVAEAGTRVELLQAEGTLRSARQQLAALWGNPDPRFTQV
EGAVDQLPAMAPAQNLGVRLAAAPVVVQARLEVERRKALSDLEQAKRIPDVTVSLGAKRV
PASDGEVGGSRRNQVVVGLSVPLPIFDTNRGNVAEALSREEKARDDLAAAELQLGTEVAQ
ATERLRSARATAETLQHDALPGAETAYKAATKGFELGKFSFLEALDAQRTLFQVRAQYLL
SLADAHRAAGELDRLLGNEGDDISPVTPAAPVAR