Protein Info for GFF4683 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01315: Ald_Xan_dh_C
  • amino acids 22 to 132 (111 residues), 107.3 bits, E=8.4e-35
• PF02738: MoCoBD_1
  • amino acids 170 to 405 (236 residues), 236.7 bits, E=3.4e-74
• PF20256: MoCoBD_2
  • amino acids 441 to 697 (257 residues), 204.1 bits, E=5.1e-64

Predicted SEED Role

"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)

MetaCyc Pathways

• adenosine nucleotides degradation II (5/5 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• guanosine nucleotides degradation II (4/4 steps found)
• purine nucleotides degradation II (aerobic) (9/11 steps found)
• superpathway of guanosine nucleotides degradation (plants) (5/6 steps found)
• guanosine nucleotides degradation I (3/4 steps found)
• guanosine nucleotides degradation III (3/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purines degradation in plants (12/18 steps found)
• purine nucleobases degradation II (anaerobic) (15/24 steps found)
• caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
• theophylline degradation (1/9 steps found)
• caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.17.1.4

Use Curated BLAST to search for 1.17.1.4

Protein Sequence (767 amino acids)

>GFF4683 Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MHATLPLALHEEPRADYLQKVTGTAIYASDVEVPGMLHGKILRSTVPHARIRRIDVSAAL
AMPGVVAVLTGDDLKDLPGTEIRWGLSLRDRPVIALDKVRYVGDPVAAVAAVDEGTAEEA
LDAITVDYDTLPYATTAQEAMAEGAALVHDDMDRLKDYYFRGEATPVEGTNIFQQWQYAC
GDVDQAFSTAARVFEDTFTFPMVFHYAMEPHVCVAHWKPGSLEIWSGGQTPTAIQRVCSE
ILGVPLACVRVHSPYVGGGFGGKASVKIDPLVAALSWKARAPVRVCLSIAESMLTCRRLD
AEIALKTAVDGAGRIVAKSIRAVLNGGAYADTGPAIAIKAAIRAIGPYHIPNLRLEAVGV
YTNTVPGAAFRSIGGPQAVWATESQMDIMAAALGRDPVEFRLANMADKGQTIKPDLRPLD
VDMRNSLRKAVAALERLPEPTHTRRRGRGVAVGVSDPGIVPVGGAIVRLRADGSINVSAN
TVEIGQGSRGVLRIIAHKALGQPLRRIAVAEPDTLQAPYDWGTGASRSTVIIGLAVQLAC
EDIVRQVQETAAQVLGGSPQAYQLGEGCVEGPDGPVSILDLLRRFNGMAAGEFLGVGRVN
SNTRNGDFKLAPLFWETGAGACEIEVDEGTGAIRVTRVGGAADLGHVINRKAAEGQDEGA
MVMGLGHTLSEEYVYEDGQVVNGTLFDYKVPTMEDAPRHVGTTLIESGDGPGPFGARGGG
EGAILPVAPAVANALFQGWGVRIKELPLTPERVWRALQAAKAETKNQ