Protein Info for GFF4672 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: DNA-binding domain of ModE / Molybdate-binding domain of ModE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 274 TIGR00637: ModE molybdate transport repressor domain" amino acids 29 to 117 (89 residues), 103 bits, see alignment E=7.3e-34 PF00126: HTH_1" amino acids 34 to 94 (61 residues), 41.5 bits, see alignment E=1.1e-14 TIGR00638: molybdenum-pterin binding domain" amino acids 133 to 201 (69 residues), 76.9 bits, see alignment E=9.7e-26 amino acids 206 to 272 (67 residues), 60.7 bits, see alignment E=1e-20 PF03459: TOBE" amino acids 135 to 198 (64 residues), 58.3 bits, see alignment E=7.3e-20 amino acids 208 to 270 (63 residues), 53.5 bits, see alignment E=2.2e-18

Best Hits

Swiss-Prot: 41% identical to MOPA_RHOCA: Molybdenum-pterin-binding protein MopA (mopA) from Rhodobacter capsulatus

KEGG orthology group: K02019, molybdate transport system regulatory protein (inferred from 52% identity to adn:Alide_2461)

Predicted SEED Role

"DNA-binding domain of ModE / Molybdate-binding domain of ModE" in subsystem Molybdenum cofactor biosynthesis or Transport of Molybdenum

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (274 amino acids)

>GFF4672 DNA-binding domain of ModE / Molybdate-binding domain of ModE (Hydrogenophaga sp. GW460-11-11-14-LB1)
MVTKRRKGGDRLDVRGSIWISVGGDSLGGHGRVALLRAVDKHGSITQAAKAFGMSYKAAW
DAINRMNELSRTPLIERAVGGKGGGSTRLTEHGRLLIERYEKVDAIHQRFVELLDQGAMD
LDQEFSILKVLNMKTSARNQWIGKVTAVRSGAVNDEVEVTLPGGQRLAAIITRESTQTLG
LKTELPVVVLVKASSVLLATDLQGAKVSARNRIEGTVHAIAPGAVNAEVTLKTEDGLNVV
AIVTQGAVSELGLATGVTVTALVKASDVILAVAS