Protein Info for GFF4657 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Esterase/lipase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 344 PF00135: COesterase" amino acids 95 to 194 (100 residues), 31.1 bits, see alignment E=1.9e-11 PF20434: BD-FAE" amino acids 97 to 197 (101 residues), 70 bits, see alignment E=3.1e-23 PF07859: Abhydrolase_3" amino acids 105 to 317 (213 residues), 221.1 bits, see alignment E=2.2e-69

Best Hits

KEGG orthology group: None (inferred from 68% identity to pna:Pnap_1944)

Predicted SEED Role

"Esterase/lipase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (344 amino acids)

>GFF4657 Esterase/lipase (Hydrogenophaga sp. GW460-11-11-14-LB1)
MVQGLHGSRKRQPQSHPMPTSPDPRDLLTPMMRGVLDRIARAGHPPLHALPPDKAKAAYE
AGAGVLEIPSQPMARVEDLRIPARDGAELPARLFVPEANHPLPVLLYFHGGGFTVGSVAT
HGPLCRELAHLAGCAVLSLDYRLAPEAKFPTAVHDAWDSLVWLRGQAGALGLDGTRIAVG
GDSAGGTLAAVTAIAARDAGWPLALQCLFYPGCAGHQDTVSHQTFAKGFLLEEADISYFF
GHYLRSAADRDDWRFAPLDGVDESGHARDLDDVAPAWIGLAECDALTDEGVMYADRLRHA
GVAVDLEIYAGVVHGFINFGRAIPQARTAHQHAALALRNAFGAA