Protein Info for GFF4645 in Variovorax sp. SCN45

Annotation: GGDEF domain protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 505 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details transmembrane" amino acids 281 to 302 (22 residues), see Phobius details PF02743: dCache_1" amino acids 34 to 261 (228 residues), 59 bits, see alignment E=5.2e-20 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 330 to 497 (168 residues), 175.6 bits, see alignment E=3.5e-56 PF00990: GGDEF" amino acids 334 to 495 (162 residues), 164.6 bits, see alignment E=1.7e-52

Best Hits

KEGG orthology group: None (inferred from 63% identity to del:DelCs14_2317)

Predicted SEED Role

"GGDEF domain protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (505 amino acids)

>GFF4645 GGDEF domain protein (Variovorax sp. SCN45)
VKRDVRLAKLLLLAVVVCVSAATCWQLWSARRHTLAEIDVNNLNLAQALNTYSEGIFTES
AMLLLGVAERLEAEGDGPAHLRRVQALVSRQEHLLNQLNGLSILDARGDWVMHSRGSFAP
GTNSADRAYFIHHRDKRSQDIFIGSPVRSQFTGDWVITVSRRLEDGQGNFAGVIVVALGI
ENFLRAFGTIDLGGSGAISLATSGGQLLVRYPYREQDVGRDFSKSPNFLRRYAGTSGTAS
FRSSLDGVQRLYAFRTSERYPLVTTVSLGKDDALQAWRRQALLTLGVVGALLAVVAAVGR
RLIINIQRRMSAEASLMAAREDLLQANRRLEVLATQDQLTGLANRRSFDDVLARECRRTA
REGTPLSLLLLDLDYFKHFNDTYGHVAGDRCLRAVADALQQGVRRPGDLVARYGGEEVAI
ILPNTDLPGALSVAEQLLERVRALGIAHAASPHERVTLSIGAASLHGMQANRAEQRLIEA
ADRALYRAKESGRNRAMGHEEPVDA