Protein Info for GFF4635 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Predicted cobalt transporter CbtA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 269 signal peptide" amino acids 1 to 36 (36 residues), see Phobius details transmembrane" amino acids 81 to 104 (24 residues), see Phobius details amino acids 113 to 133 (21 residues), see Phobius details amino acids 153 to 171 (19 residues), see Phobius details amino acids 178 to 198 (21 residues), see Phobius details amino acids 218 to 242 (25 residues), see Phobius details PF09490: CbtA" amino acids 3 to 242 (240 residues), 135 bits, see alignment E=2.1e-43

Best Hits

KEGG orthology group: None (inferred from 80% identity to bpt:Bpet1412)

Predicted SEED Role

"Predicted cobalt transporter CbtA" in subsystem Coenzyme B12 biosynthesis or Transport of Nickel and Cobalt

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (269 amino acids)

>GFF4635 Predicted cobalt transporter CbtA (Hydrogenophaga sp. GW460-11-11-14-LB1)
MIFRRLIWAALAVAMLVGSLQTGLQQWQTMPIILAAEGFESQKVETALAVADTHAHGDGA
AHDHGDAEAWAPAEGVERQLWSWVAHVLHAFSMALLVLAVMAVCQWRGTTLRALPLAAWV
AAAGWLSFHFWPSIGLHAEIPGMDAARLGSRQGWWVLAAGAAALACASVALMRTPLRWAV
AAGWLALPFVVGAPHIMADPLAGFTGEAQVALRQLGSQFIWATTWLSLSFWVSMGALAGL
AFQRWLRPAVAALLERSDAGHASAMKAPQ