Protein Info for GFF4622 in Xanthobacter sp. DMC5

Annotation: Cytochrome c oxidase subunit 1 , bacteroid

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 554 transmembrane" amino acids 21 to 41 (21 residues), see Phobius details amino acids 47 to 67 (21 residues), see Phobius details amino acids 89 to 117 (29 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 169 to 192 (24 residues), see Phobius details amino acids 204 to 226 (23 residues), see Phobius details amino acids 238 to 258 (21 residues), see Phobius details amino acids 282 to 303 (22 residues), see Phobius details amino acids 314 to 332 (19 residues), see Phobius details amino acids 351 to 372 (22 residues), see Phobius details amino acids 384 to 404 (21 residues), see Phobius details amino acids 428 to 448 (21 residues), see Phobius details amino acids 461 to 487 (27 residues), see Phobius details amino acids 511 to 533 (23 residues), see Phobius details TIGR00780: cytochrome c oxidase, cbb3-type, subunit I" amino acids 84 to 548 (465 residues), 722.4 bits, see alignment E=1.3e-221 PF00115: COX1" amino acids 89 to 521 (433 residues), 387.9 bits, see alignment E=3.3e-120

Best Hits

Swiss-Prot: 86% identical to FIXN_AZOC5: Cytochrome c oxidase subunit 1 homolog (fixN) from Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / NBRC 14845 / NCIMB 13405 / ORS 571)

KEGG orthology group: K00404, cb-type cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 90% identity to xau:Xaut_0459)

MetaCyc: 67% identical to cytochrome cbb3 oxidase subunit I (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (554 amino acids)

>GFF4622 Cytochrome c oxidase subunit 1 , bacteroid (Xanthobacter sp. DMC5)
MTTLQAPIQPPAKSLRWGEGALIGVFSLFALFSIVVAAKAYTPEYAFHAYLFAAASIASV
FAIGNRYMNRPAGAVPQFIDGKPNYNMGVVKFATVAAVVWGIAGFLVGVIAALQLAFPIV
NLDLPWISFGRLRPLHTSAVIFAFGGNVLLATSFYVVQRTSRARLAGDLAPWFVILGYNF
FIVIAGTGYLLGITQGKEYAEPEWYSDLFLTVVWVTYLLVFLVTLLKRNEPHIYVANWFY
LAFIITIAVLHLGNNATIPVSVFSPKSYILWSGVQDAMFQWWYGHNAVGFFLTAGFLALM
YYFIPKRAERPVYSYRLSIVHFWALIFIYIWAGPHHLHYTALPDWAQTLGMTFSVILWMP
SWGGMINGLMTLSGAWDKLRTDPVIRMMVVAVAFYGMSTFEGPMMSVKAVNSLSHYTEWT
IGHVHSGALGWVAYISFGAIYCLVPWLWNKREMYSVKAINWHFWVSTLGIVLYISSMWVA
GILQGLMWRAYTQLGFLEYSFIETVEAMHPLYVIRALGGILFLTGALIMAWNVWKTITTP
QTAAERELALQAAE