Protein Info for GFF4619 in Variovorax sp. SCN45

Annotation: Altronate dehydratase (EC 4.2.1.7)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08666: SAF
  • amino acids 13 to 77 (65 residues), 25.6 bits, E=2.1e-09
• PF04295: GD_AH_second
  • amino acids 113 to 259 (147 residues), 158.7 bits, E=1.3e-50
• PF20629: GD_AH_C
  • amino acids 269 to 510 (242 residues), 345.9 bits, E=1.7e-107

Best Hits

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 94% identity to vpe:Varpa_0806)

MetaCyc: 70% identical to D-arabinonate dehydratase (Herbaspirillum huttiense)
Arabinonate dehydratase. [EC: 4.2.1.5]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• D-galacturonate degradation I (3/5 steps found)
• superpathway of hexuronide and hexuronate degradation (6/10 steps found)
• D-arabinose degradation III (3/6 steps found)
• D-arabinose degradation IV (3/6 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (17/31 steps found)
• superpathway of pentose and pentitol degradation (16/42 steps found)

KEGG Metabolic Maps

• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.5 or 4.2.1.7

Protein Sequence (512 amino acids)

>GFF4619 Altronate dehydratase (EC 4.2.1.7) (Variovorax sp. SCN45)
MTPYIRLHPADDVVIARSQLLGGTTVENVAVRGLIPPGHKIAMRDIAQGEPVRRYNQIIG
FASRPIAAGEHVHTQNLNMGPDKGASTGDFERDYAFGADVKPAPARREATFMGIKRADGR
VATRNYIGVLTSVNCSATAARAIADHFSRKTNPQALAAFPNVDGVIALTHGTGCGMDTQG
MGMQILERTLTGYATHPNFAGVLVVGLGCEANQINAWLATGHLAEGENFRTFNIQDTGGT
RKTVEKGVALIEEMLPRANAVKREPCSAAHITIGLQCGGSDGYSGISANPALGAAVDLLV
AHGGTAILSETPEVYGAEHLLTRRAVKREVGQKLVDRIKWWEHYTEINQGEMNNNPSPGN
KAGGLTTILEKSLGAVAKGGTSNLEAVYEYAEPVTAHGFVYMDTPGYDPVSATGQVAGGA
NLICFTTGRGSAYGCAPSPSLKLATNSALWQRQEEDMDINCGEIVDGTASIQEMGQRIFE
LVLATASGAHSKSEQHGYGQNEFVPWQVGAVM