Protein Info for GFF4603 in Variovorax sp. SCN45

Annotation: Short-chain dehydrogenase, associated with 2-hydroxychromene-2-carboxylate isomerase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 249 signal peptide" amino acids 1 to 14 (14 residues), see Phobius details PF00106: adh_short" amino acids 6 to 202 (197 residues), 116.2 bits, see alignment E=2.1e-37 PF08659: KR" amino acids 9 to 173 (165 residues), 23.9 bits, see alignment E=5.3e-09 PF13561: adh_short_C2" amino acids 18 to 200 (183 residues), 92.8 bits, see alignment E=4e-30

Best Hits

KEGG orthology group: None (inferred from 96% identity to vpe:Varpa_0842)

Predicted SEED Role

"Short-chain dehydrogenase, associated with 2-hydroxychromene-2-carboxylate isomerase family protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (249 amino acids)

>GFF4603 Short-chain dehydrogenase, associated with 2-hydroxychromene-2-carboxylate isomerase family protein (Variovorax sp. SCN45)
MATLQKAALIVGAGDATGGAIARRFAREGFATCVTRRSLDKLQPLVAQIEADGGRAHAFA
CDARKEEEVVALVEQIESTIGPIEVMVFNIGANVPESILNETARKYFKVWEMACFSGFLN
GREVAKRMVAREIPQGGHRGTIIFTGATASLRGAANFGAFSGAKMALRALAQSMARELGP
QGIHVAHVVVDGAIDTEFIRSNFPERYALKENDGILNPDHIADSYWMLHAQPRDAWTHEL
DLRPWSEKF