Protein Info for GFF459 in Variovorax sp. SCN45

Annotation: Beta-lactamase class C-like and penicillin binding proteins (PBPs) superfamily / DUF3471 domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 PF00144: Beta-lactamase" amino acids 5 to 329 (325 residues), 238 bits, see alignment E=1.6e-74 PF11954: DUF3471" amino acids 375 to 472 (98 residues), 60.6 bits, see alignment E=1.8e-20

Best Hits

KEGG orthology group: None (inferred from 70% identity to vpe:Varpa_3387)

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (481 amino acids)

>GFF459 Beta-lactamase class C-like and penicillin binding proteins (PBPs) superfamily / DUF3471 domain (Variovorax sp. SCN45)
MWSDLERLVEASMREWKIPGLALAVVRDGELVHQKGYGVRDMRGAEPVTPETQFLLCSIT
KSLTAAGLGLLIDEGRLEWNRPVREVIPEFRLHDALATERLTVRDLLCHRSGLPRHDWVH
MPGDLGGAQMLPLLRHLAPSRELRDTFQYSNLGYMVAGMVTERISGQRWEDFTTERLLKP
LGFKDFGFTIEALEAADNAARPHAMVGDECVPSPLWPIRTTAGGGMNVSLADIAKWARFL
LDEGKVNGAQLLSAKSLREMCTPHVHMGRSEHAEIGDSHYGFGLFCENYRGDRTYAHSGS
WLGWGTLMTVVPERRTAVVVLTNRAPSTVTSILTYAVLDHVSGREPVDWFARLQPKRREF
VEQQKSERATREDKRRKDTQPSHALDEYVGVYAHPAYGRIEIAREAEGLAWRWRTFSGPL
AHWHYDVFHTPHRPAEFHPDELALTFLYDREGRIDRIAAPFEPAVADIVFQRTDAKAEPA
A