Protein Info for GFF4581 in Sphingobium sp. HT1-2

Annotation: CzcABC family efflux RND transporter, transmembrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1075 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 365 to 384 (20 residues), see Phobius details amino acids 391 to 410 (20 residues), see Phobius details amino acids 417 to 437 (21 residues), see Phobius details amino acids 475 to 494 (20 residues), see Phobius details amino acids 502 to 529 (28 residues), see Phobius details amino acids 560 to 583 (24 residues), see Phobius details amino acids 897 to 916 (20 residues), see Phobius details amino acids 923 to 942 (20 residues), see Phobius details amino acids 948 to 973 (26 residues), see Phobius details amino acids 997 to 1015 (19 residues), see Phobius details amino acids 1026 to 1049 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1052 (1052 residues), 1445.1 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1050 (1045 residues), 983.5 bits, see alignment E=5.6e-300

Best Hits

Swiss-Prot: 56% identical to NCCA_ALCXX: Nickel-cobalt-cadmium resistance protein NccA (nccA) from Alcaligenes xylosoxydans xylosoxydans

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 59% identity to ccs:CCNA_02809)

MetaCyc: 53% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1075 amino acids)

>GFF4581 CzcABC family efflux RND transporter, transmembrane protein (Sphingobium sp. HT1-2)
MIAPIVTWAVHKRWLVLLLTAIAAVIGAAALSRLPIDAVPDITNNQVQINVRAPALSPEL
VEKQVAFPIETALAGIPGLEYSRSLSRNGFAQVTAVFSDQTDIFFARQQVGERLTGVSEN
LPDGVTPEMGPIATGLGEVYMWTVRLEHRKDDKHQPGEPGMQPDGSYITPEGERLTNDTD
KATYLRTAQDWIVSPLLKNTQGLAGVDSIGGYAKQFLVVPDVQRLASMGITLTQLSTALE
RNNTSVGGGFVNRNGEGLAVRADALVRNADELSKIVVATREGVPITLGQVASVRTGQAIR
MGSASENGTEVVVGTAIMRIGENSRTVATAVANRLEEINASLPPDVIVQPVLNRTALVNS
TIKTVAKNLGEGAVLVIVVLFLLLGNFRAALIAAVIIPVTMMLTGFGMLRAGVSANLMSL
GALDFGLIVDGAVIIVENALRRMAEHQHHEGRLLTVKERLDTVASAAREMIKPSVYGQAI
IILVYVPLLTLTGVEGKTFVPMALTVIIALVCAFILSLTFVPAAIALWLSKRIEEKEGRI
MSWLKARYEPGLDRAMKRPVVTVGAGVGGFVLAILAFMSLGQVFLPQLDEGDLLIQALRI
PATSVQQSQAMQVPIEQMMSKQPEVKFVFSKTGTAELASDPMPPNATDMFVILKDRKEWP
DPSLKKEELISRIEGELAKFPGNAYEITQPIQMRFNELIAGVRGDIAVKVFGDDFNSMNA
TAEKIASVLRRTQGAADVKVEQTTGLPMLDIRVNRDAMARLGVTAQDVQDIVNATLGGQQ
SGMIFEGDRRFPVVIRLSEDQRGDISLLSQVQVPTPSGQFVPLASVADIRVVDGPNQISR
ENGKRRVVVQANVRGRDVGGVVADAQAAIGKEVRLPPGSYLEWGGQFENLASAQERLQLV
IPACFVLILLLLYGALGSVRDAAIVFTGVPLALVGGVLALFLRGMDFSISAAVGFIALSG
IAVLNGLVMVSSIQDLMRTGMERAEAARVGALQRLRPVVMTALVASLGFVPMALGSGAGA
EVQKPLATVVIGGLISATLLTLFVLPTLYARYGRTTMVEEDDPEIEVSPSVQPQH