Protein Info for GFF4573 in Variovorax sp. SCN45

Annotation: L-carnitine dehydratase/bile acid-inducible protein F

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02515: CoA_transf_3
  • amino acids 10 to 377 (368 residues), 429.1 bits, E=7.6e-133

Best Hits

KEGG orthology group: None (inferred from 96% identity to vpe:Varpa_0875)

MetaCyc: 47% identical to succinyl-CoA-glutarate CoA-transferase (Pseudomonas putida)
Succinate--hydroxymethylglutarate CoA-transferase. [EC: 2.8.3.13]

Predicted SEED Role

"L-carnitine dehydratase/bile acid-inducible protein F (EC 2.8.3.16)" (EC 2.8.3.16)

MetaCyc Pathways

• L-lysine degradation X (4/6 steps found)
• oxalate degradation II (1/3 steps found)
• L-lysine degradation IV (2/5 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

Isozymes

Compare fitness of predicted isozymes for: 2.8.3.16

Use Curated BLAST to search for 2.8.3.13 or 2.8.3.16

Protein Sequence (402 amino acids)

>GFF4573 L-carnitine dehydratase/bile acid-inducible protein F (Variovorax sp. SCN45)
MSSLNSSLPLAGVRVLDLSRILAGPWCGMVLADMGAEVIKVEHPGRGDDTRDWGLRVGKT
ETAYFNSVNRNKRSVTLDLQTPEGQQLARDLAKQCDVVIQNFKFGGIDKLGLGYEQLRKE
NPRLIYCSISGYDRTGPEAARPGYDLVVQGEAGLMALNGEADQPPLKFGVAAVDLFTGMY
SAQAILAALYQREKTGQGRHVEMALFDCGLMITAYYGLEALLMGEDPPRYGNSHPSIVPY
GVFDAADGPLVITVGNNAQFARFCTEVIGRPDLAADERFKTNILRSANRAVLLPELHAEL
AKRQRADLLEKLTAAGIPCGEVLGLLEALQSKRASDAGLVTTQPHPVAGTVNVLAPPYRF
DGERLPVRSAPPTLGEGTHDVLQSLLGLSDEKLAALKTSGVV