Protein Info for GFF4553 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: N-succinyl-L,L-diaminopimelate aminotransferase alternative (EC 2.6.1.17)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR03538: succinyldiaminopimelate transaminase
  • amino acids 1 to 403 (403 residues), 597.3 bits, E=6.3e-184
• PF00155: Aminotran_1_2
  • amino acids 32 to 399 (368 residues), 164.6 bits, E=1.9e-52

Best Hits

KEGG orthology group: K14267, N-succinyldiaminopimelate aminotransferase [EC: 2.6.1.17] (inferred from 77% identity to mpt:Mpe_A1807)

MetaCyc: 62% identical to N-succinyldiaminopimelate-aminotransferase (Bordetella pertussis)
Succinyldiaminopimelate transaminase. [EC: 2.6.1.17]

Predicted SEED Role

"N-succinyl-L,L-diaminopimelate aminotransferase alternative (EC 2.6.1.17)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.6.1.17)

MetaCyc Pathways

• aspartate superpathway (24/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)

KEGG Metabolic Maps

• Lysine biosynthesis

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.6.1.17

Protein Sequence (407 amino acids)

>GFF4553 N-succinyl-L,L-diaminopimelate aminotransferase alternative (EC 2.6.1.17) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNPLLSRLQPYPFERLRKLFADVTPNPALRPISLGIGEPKHAAPDFLKQALAASLDTGLS
SYPATAGTPALREACAAWVQRRYGVTLDPTSQLLPVNGSREALFAFAQTVIDPTRPGATV
VMPNPFYQIYEGAALLGGAEPYYVASDPARNFAAAWDSVPEAVWARTQLLFVCSPGNPAG
AVMPLDEWQRLFELSDRHGFVIASDECYSEIYFRDDAPLGGLEAAQRLGRSDFRRLMMFT
SLSKRSNVPGLRSGFVAGDASLIKPFLLYRTYHGGAMSPVVQAASVAAWGDEDHVVDNRR
QYREKFAQVTPLLAEVLDVALPDASFYLWAAVPASFADAAAGLSADEAFARELLAQYNVT
VLPGSYLAREVGGVNPGTGRVRMALVAEPAECLEAAGRIQAFLSRRA