Protein Info for GFF4540 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 318 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 123 to 293 (171 residues), 123.4 bits, see alignment E=3.9e-40 PF00990: GGDEF" amino acids 125 to 290 (166 residues), 127.5 bits, see alignment E=2.2e-41

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

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Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (318 amino acids)

>GFF4540 diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MIDYHLPLLNTSEAVLVMSADLRLEFANPAALRMMGFEGNTPPDLSLRHMLDERSAALAA
TIEDHLVVEGHWKGDIWLRRSDEGALPVRLVVDRYHDTNGFRHACVMSDISLRKQTEARL
IELSQLDSLTGLFNRSHFMQQLDNHLNLLHQEELQYALLFVDVDDLKHINDTLGHLIGDL
CLCEVARRLGLAVRHSQQAAGHHPASNPLVARIGGDEFVILLSISDCEEARRIATSINEL
MLVPWQPNERHQLVISTSIGIAYAPLHGRSGKTLLQLADRAMYHAKNSRKGSVHEFIQQN
PQVPLRFETGFDTLPSED