Protein Info for GFF4537 in Variovorax sp. SCN45

Annotation: Tetrapartite efflux system, inner membrane component FusBC-like

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 710 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 38 to 55 (18 residues), see Phobius details amino acids 62 to 82 (21 residues), see Phobius details amino acids 88 to 106 (19 residues), see Phobius details amino acids 113 to 135 (23 residues), see Phobius details amino acids 149 to 174 (26 residues), see Phobius details amino acids 386 to 406 (21 residues), see Phobius details amino acids 412 to 430 (19 residues), see Phobius details amino acids 440 to 459 (20 residues), see Phobius details amino acids 465 to 483 (19 residues), see Phobius details amino acids 489 to 507 (19 residues), see Phobius details amino acids 513 to 533 (21 residues), see Phobius details PF04632: FUSC" amino acids 14 to 698 (685 residues), 611.8 bits, see alignment E=2.9e-187 PF06081: ArAE_1" amino acids 19 to 125 (107 residues), 24.1 bits, see alignment E=5.3e-09 PF13515: FUSC_2" amino acids 26 to 156 (131 residues), 47.8 bits, see alignment E=2.5e-16

Best Hits

KEGG orthology group: None (inferred from 87% identity to vpe:Varpa_0909)

Predicted SEED Role

"Inner membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (710 amino acids)

>GFF4537 Tetrapartite efflux system, inner membrane component FusBC-like (Variovorax sp. SCN45)
VASFSLPRFSRAELLFSGKSFVAAMLAMYLASRAGLPRPFWALMTTYVVAHPLAGAVRSK
AVYRFCGTLIGSTATVLLVPALSNAPELLTLVLALWVGLCLCISLFDRTPRSYVFMLAGY
TAALIGFPSVQTPLALFDTAVARVEEIGLGIFCATLIHSLVLPAGLAPTVLGLLDRTLLD
ARKWLGDLLQPAAHGGGNGANGGEPKRLDDDRRRLAGDITQLRLLSTHVPFDTTHLRWTA
GAIRAMQDRVAALTPALSAVEDRLQALAQAEGRLAPDVTAVLAQAAQWLREEAEPGADAA
TRAERLQTLRRAIDALSATPANAQPQHTAWGRALRIGLAGRLEELVDGWTACAQLRQDID
EGLKGAAPLRRTAALGSRVLHRDYGMALLSALAAVIAICLCGAFWILTGWPMGSAATMMA
AVFCCFFATMDDPVPAIHGFLKWTLWSIPISALYVLVLMPMVQDFGMLVLICAPLLLLLG
LYLPRPTHFMAAMALIFGVCGTLALHDTASSDLVSFINSMIGQVVGVVVAARVTRLVRSV
GADWSARRIQRATWRELGDMAASSQPQYAQSDAYAVRMLDRIGLLAPRIAQAGGTVEGVA
ANDALRDLRMGADIAVLQRVRGQLPTSTSAALLGGIARFFRQRGEGRMNPRPADLLPQID
EALNAVLGAPASAAPAASRSAVTALVGLRRNLFPDAPPMLAGAPVQGASA