Protein Info for GFF4526 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.61)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 183 PF03802: CitX" amino acids 13 to 176 (164 residues), 176.3 bits, see alignment E=2.1e-56 TIGR03124: holo-ACP synthase CitX" amino acids 13 to 175 (163 residues), 192.9 bits, see alignment E=1.8e-61

Best Hits

Swiss-Prot: 82% identical to CITX_CITK8: Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (citX) from Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)

KEGG orthology group: K05964, holo-ACP synthase [EC: 2.7.7.61] (inferred from 97% identity to see:SNSL254_A0674)

MetaCyc: 75% identical to apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (Escherichia coli K-12 substr. MG1655)
Citrate lyase holo-[acyl-carrier-protein] synthase. [EC: 2.7.7.61]

Predicted SEED Role

"Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.61)" (EC 2.7.7.61)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.7.7.61

Use Curated BLAST to search for 2.7.7.61

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (183 amino acids)

>GFF4526 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase (EC 2.7.7.61) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MRLFPELATCHDVSIPELLASRDERQARQRAWLTRHATPLVSFTVVAPGPIKDSALTRRI
FNHGVTALHTLAEEYGWTIREQAALASASGPEGLLAIDAPAQALKQATIALEQRYPLGRL
WDIDVLTAEGEILSRRHFALPARRCLLCGQSAAECARGKTHALTDLLIHMEALLHDADSR
QPD