Protein Info for GFF452 in Variovorax sp. SCN45

Annotation: Chloride channel protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 571 transmembrane" amino acids 26 to 51 (26 residues), see Phobius details amino acids 71 to 92 (22 residues), see Phobius details amino acids 165 to 192 (28 residues), see Phobius details amino acids 199 to 221 (23 residues), see Phobius details amino acids 241 to 262 (22 residues), see Phobius details amino acids 274 to 293 (20 residues), see Phobius details amino acids 312 to 334 (23 residues), see Phobius details amino acids 341 to 365 (25 residues), see Phobius details amino acids 372 to 397 (26 residues), see Phobius details amino acids 402 to 421 (20 residues), see Phobius details PF00654: Voltage_CLC" amino acids 81 to 422 (342 residues), 293.3 bits, see alignment E=2.7e-91 PF00571: CBS" amino acids 451 to 498 (48 residues), 17.4 bits, see alignment 4.5e-07

Best Hits

KEGG orthology group: K03281, chloride channel protein, CIC family (inferred from 61% identity to bgl:bglu_1g16190)

Predicted SEED Role

"Chloride channel protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (571 amino acids)

>GFF452 Chloride channel protein (Variovorax sp. SCN45)
MRPASVFLNIRSALQRLFGVSGWQSMLLWSIAAGLLGTLATELFRAALYGFEHLLLGPGE
GLVAMAKHLPWWARIACPTLGGLVAGLLLVLAKRVAVRSATSDYMEAIVLGDGRIPVAQT
LVRSASSLVSIGTGGSIGREGSMVQLAALAASQLGRLLRFPAERLRLLVACGAAAGLTAA
YNAPIAGAFFVAEIVLGSIAMESVGPIIIASVVANVAMRALPGYQPPYKMPAFPEIHGTE
VILFCVLGVLLGFAAVGFLRALQGSRALFAKLPIALPWRLALGGLLMGAISVPMPEVWGN
GYSVVNAVLHTPWPWTLIAMVLVAKAAATMATAGSGAVGGVFTPALFFGCMIGALFGLAV
QALWPASSSAPFAYAIVGMGAFLAGATQAPLMAILMIFEMTLSYQVMLPLMAASVIAYFV
ARSANAGSMYEITLRRNEQRDAQLRLRGLHVRDLVQPAETVVGPDADREAMSKLFLQHPV
KYLYVVDAQGRYLGVVPLAALGAAPAETSAGALLSQVILPITADTGLGEALQRFLEHRGE
RLPVIESEANPMLLGVAAKSALLATYVRLSE