Protein Info for GFF4494 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Ferric enterobactin uptake protein FepE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 378 transmembrane" amino acids 43 to 61 (19 residues), see Phobius details amino acids 338 to 358 (21 residues), see Phobius details PF02706: Wzz" amino acids 26 to 122 (97 residues), 60.5 bits, see alignment E=7.8e-21

Best Hits

Swiss-Prot: 73% identical to FEPE_ECOLI: Ferric enterobactin transport protein FepE (fepE) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to sew:SeSA_A0747)

Predicted SEED Role

"Ferric enterobactin uptake protein FepE" in subsystem Siderophore Enterobactin

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (378 amino acids)

>GFF4494 Ferric enterobactin uptake protein FepE (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MPSLNVKQEKNQSFAGYSLPPANSHEIDLFSLIEVLWQAKRRILATVFAFACVGLLLSFL
LPQKWTSQAIVTPAESVQWQGLERTLTALRVLDMEVSVDRGSVFNLFIKKFSSPSLLEEY
LRSSPYVMDQLKGAQIDEQDLHRAIVLLSEKMKAVDSNVGKKNETSLFTSWTLSFTAPTR
EEAQKVLAGYIQYISDIVVKETLENIRNQLEIKTRYEQEKLAMDRVRLKNQLDANIQRLH
YSLEIANAAGIKRPVYSNGQAVKDDPDFSISLGADGISRKLEIEKGVTDVAEIDGDLRNR
QYHVEQLAAMNVSDVKFTPFKYQLSPSLPVKKDGPGKAIIIILAALIGGMMACGGVLLRH
AMVSRKMENALAIDERLV