Protein Info for GFF4475 in Sphingobium sp. HT1-2

Annotation: Copper/silver efflux RND transporter, transmembrane protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 transmembrane" amino acids 13 to 31 (19 residues), see Phobius details amino acids 340 to 358 (19 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 445 to 465 (21 residues), see Phobius details amino acids 485 to 505 (21 residues), see Phobius details amino acids 538 to 555 (18 residues), see Phobius details amino acids 873 to 891 (19 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 979 to 999 (21 residues), see Phobius details amino acids 1007 to 1032 (26 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 2 to 1041 (1040 residues), 1411.4 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1032 (1027 residues), 791.7 bits, see alignment E=4.9e-242

Best Hits

Swiss-Prot: 68% identical to SILA_SALTM: Putative cation efflux system protein SilA (silA) from Salmonella typhimurium

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 83% identity to aex:Astex_3842)

MetaCyc: 69% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1046 amino acids)

>GFF4475 Copper/silver efflux RND transporter, transmembrane protein CusA (Sphingobium sp. HT1-2)
VIAHLIRWSVRNRFFVMIGVLTLIGVGVWAVRSTAIDALPDLSDTQVIIRTSYPGQAPQI
VENQVTYPLTTTMLSVPGAKTVRGYSFFGDSFVYVIFEDGTDLYWARSRVLEYLNQVQGR
LPASARSALGPDATGVGWVYEYALVDRTGRHDLSQLRGLQDWFLRYELKTVTGVAEVASI
GGMVKQYQVLLDPVKLAAYGVTHAQTVDAIQKANQESGGSVLEMAEAEYMVRVSGYLKTL
DDFRAIPLRTAAGGVPVRLGDVATIQAGPEMRRGIAELNGEGEVAGGVVILRSGKNARET
IAAVKDKLAELKKGLPPGVDVVTVYDRSQLIDRAVENLTHKLVEEFIVVAIVCGLFLWHV
RSALVAILTLPLGVLAAFVVMRFQGVNANIMSLGGIAIAIGAMVDAAVVMIENAHKKIER
WEEDHPDEHLEGDTRWTVITEAAAEVGPALFFSLLIITLSFIPVFTLEGQEGRLFAPLAF
TKTYAMASAAILSVTLVPVLMGLLIRGKIPPEQSNPVNRWLTNIYRPALDWTMRRPRTVL
LIAALAFATTAWPLTQLGGEFMPKMEEGDLLYMPSALPGLSAAKASDLLQQTDRLIKTVP
EVESVFGKAGRAETATDPAPLEMFETTIQFKPRDQWRPGMTPDKLVEELDRTVKLPGLAN
VWVPPIRNRIDMLATGIKSPIGVKVSGADLAELDRIAHDVETVAKTVPGVSSALAERLTG
GRYVDVDVDRAAAARFGLNITDVQRIVSGAIGGETIGETVEGLARYPISVRYPRELRDSL
DGIRMLPVLTPSGQQITLGTIARVSIAEGPPMLKTENARPSTWVYVDVRGRDLASVVSDL
QHAIARQVTLSPGVSVAYSGQFEYLQRAVAKLKLVVPATLLIIFVLLYMIFGRFDEAALI
MGTLPFALTGGIWILYLLGFNQSVATGVGFIALAGVSAEFGVVMLIYLKNALEERTDPDV
AEVETAVREGALLRVRPKAMTVAVILAALLPILLGSGAGSEVMSRIAAPMIGGMLTAPLL
SMFVLPAAYLLLRRPKMKPNDQHVSL