Protein Info for GFF4474 in Variovorax sp. SCN45

Annotation: Peptidoglycan glycosyltransferase FtsW (EC 2.4.1.129)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 432 transmembrane" amino acids 60 to 83 (24 residues), see Phobius details amino acids 98 to 119 (22 residues), see Phobius details amino acids 129 to 150 (22 residues), see Phobius details amino acids 166 to 183 (18 residues), see Phobius details amino acids 194 to 213 (20 residues), see Phobius details amino acids 219 to 236 (18 residues), see Phobius details amino acids 242 to 262 (21 residues), see Phobius details amino acids 320 to 344 (25 residues), see Phobius details amino acids 358 to 380 (23 residues), see Phobius details amino acids 396 to 419 (24 residues), see Phobius details TIGR02614: cell division protein FtsW" amino acids 58 to 422 (365 residues), 386.6 bits, see alignment E=5.5e-120 PF01098: FTSW_RODA_SPOVE" amino acids 60 to 424 (365 residues), 334.7 bits, see alignment E=3.2e-104

Best Hits

Swiss-Prot: 95% identical to FTSW_VARPE: Probable peptidoglycan glycosyltransferase FtsW (ftsW) from Variovorax paradoxus (strain EPS)

KEGG orthology group: K03588, cell division protein FtsW (inferred from 95% identity to vpe:Varpa_0978)

Predicted SEED Role

"Cell division protein FtsW" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (432 amino acids)

>GFF4474 Peptidoglycan glycosyltransferase FtsW (EC 2.4.1.129) (Variovorax sp. SCN45)
LNSAASGATPNARTSRFGGWFKRARSGIDALPVHLPVRLGGAGIAQTKATPMRVLGFDQA
LVWVTVALLTWGLIMVYSASIALPDNPRFARAGYSASYFLTRHAASVVFAFVAALLTFQI
PMKTWERAAPWLFVASLLLLVAVLIPHIGINVNGARRWLPMGFMRFQPSELAKLAMVLYA
ASYMVRKMEIKERFFRAVLPMGIAVVVVGMLVMAEPDMGAFMVIAVIAMGILFLGGVNAR
MFFVIAALVVVAFGTIVATSPWRRERIFAYLDPWSEEHALGKGYQLSHSLIAIGRGEIFG
VGLGGSVEKLHWLPEAHTDFLLAVIGEEFGLIGVLLIIGMFLWLTRRIMHIGRQAIALDR
VFSGLVAQGVGVWIGFQAFINMGVNLGALPTKGLTLPLMSFGGSAILMNLVALAVVLRID
YENRVLMRGGRV