Protein Info for GFF4469 in Variovorax sp. SCN45

Annotation: Cell division protein FtsA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 409 TIGR01174: cell division protein FtsA" amino acids 8 to 375 (368 residues), 461.5 bits, see alignment E=1.1e-142 PF14450: FtsA" amino acids 10 to 180 (171 residues), 32.1 bits, see alignment E=3.4e-11 amino acids 205 to 372 (168 residues), 117.8 bits, see alignment E=1e-37 PF02491: SHS2_FTSA" amino acids 84 to 160 (77 residues), 96.6 bits, see alignment E=2.3e-31 PF06723: MreB_Mbl" amino acids 200 to 341 (142 residues), 48.9 bits, see alignment E=1.1e-16

Best Hits

Swiss-Prot: 58% identical to FTSA_PSEAE: Cell division protein FtsA (ftsA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03590, cell division protein FtsA (inferred from 100% identity to vap:Vapar_0923)

Predicted SEED Role

"Cell division protein FtsA" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (409 amino acids)

>GFF4469 Cell division protein FtsA (Variovorax sp. SCN45)
MPKEYKDLVVGLDIGTAKVMVVVAEVLPGGELKLAGLGIAPSNGLKRGVVVNIDATVQSI
QQALKEAELMADCKISRVYTGITGSHIRGINSSGMVAVKDKEVTPADVARVVETARAINI
SSDQRLLLVEPQEFVIDGQDVKEPIGMSGMRLEAKVHIVTGAQSAAENIIKCVRRCGLEV
DQLMLNPLASSQAVLTEDERELGVVLVDIGAGTTDVAIFTNGAIRHTAVIPIAGDLITSD
IAMALRTPTKDAEDIKVENGFAKQLLADPETQVEVPGLGDRGPRMLSKQALAGVIEPRIE
EIFSLVQQVVRESGYEEVLSSGVVLTGGSAVMPGMVELGEDIFLKPVRRGIPKYSSALSD
MVAQPRAATVMGLLEEARFARMRGFKVAQKNGSVKTAFGRFKDFIVGNF