Protein Info for GFF4462 in Variovorax sp. SCN45

Annotation: Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02075: RuvC
  • amino acids 3 to 152 (150 residues), 162.7 bits, E=3e-52
• TIGR00228: crossover junction endodeoxyribonuclease RuvC
  • amino acids 3 to 157 (155 residues), 166 bits, E=2.9e-53

Best Hits

Swiss-Prot: 98% identical to RUVC_VARPS: Crossover junction endodeoxyribonuclease RuvC (ruvC) from Variovorax paradoxus (strain S110)

KEGG orthology group: K01159, crossover junction endodeoxyribonuclease RuvC [EC: 3.1.22.4] (inferred from 98% identity to vap:Vapar_0930)

MetaCyc: 48% identical to crossover junction endodeoxyribonuclease RuvC (Escherichia coli K-12 substr. MG1655)
3.1.22.4-RXN [EC: 3.1.21.10]

Predicted SEED Role

"Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4)" in subsystem DNA-replication or RuvABC plus a hypothetical (EC 3.1.22.4)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.21.10 or 3.1.22.4

Protein Sequence (182 amino acids)

>GFF4462 Crossover junction endodeoxyribonuclease RuvC (EC 3.1.22.4) (Variovorax sp. SCN45)
MRILGIDPGLQTTGFGVVDADGHALRYVASGTISTRHLGTGNLPARLKVLFDGIAEIAAR
YQPDASAVEIIFVNVNPQSTLLLGQARGACVTSLVNSNLSVAEYTALQMKKAVAGHGQAA
KAQVQEMVKRLLDLPGLPGADAADALGIAITHAQVGRSMARLAEAAELSKTHAGTYRQGR
SR