Protein Info for GFF4437 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Carbamate kinase (EC 2.7.2.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00696: AA_kinase
  • amino acids 2 to 277 (276 residues), 87.6 bits, E=5.6e-29
• TIGR00746: carbamate kinase
  • amino acids 2 to 296 (295 residues), 397.8 bits, E=1.4e-123

Best Hits

Swiss-Prot: 87% identical to ARCC_ECOLI: Carbamate kinase (arcC) from Escherichia coli (strain K12)

KEGG orthology group: K00926, carbamate kinase [EC: 2.7.2.2] (inferred from 99% identity to sed:SeD_A0580)

Predicted SEED Role

"Carbamate kinase (EC 2.7.2.2)" in subsystem Arginine Deiminase Pathway or Arginine and Ornithine Degradation or MLST or Polyamine Metabolism (EC 2.7.2.2)

MetaCyc Pathways

• allantoin degradation IV (anaerobic) (8/9 steps found)
• L-arginine degradation V (arginine deiminase pathway) (4/4 steps found)
• L-citrulline degradation (3/3 steps found)
• guadinomine B biosynthesis (2/13 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Glutamate metabolism
• Nitrogen metabolism
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.7.2.2

Use Curated BLAST to search for 2.7.2.2

Protein Sequence (297 amino acids)

>GFF4437 Carbamate kinase (EC 2.7.2.2) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKTLVVALGGNALLQRGEALTAENQYRNIADAVPALARLARSYRLAIVHGNGPQVGLLAL
QNLAWKAVEPYPLDVLVAESQGMIGYMLAQRLALEPDMPPVTAVLTRIKVSADDPAFLEP
EKFIGPVYSPEEQMALEATYGWHMKRDGKYLRRVVASPAPRQIIESAAIELLLKEGHVVI
CSGGGGVPVAGEGEGVEAVIDKDLAAALLAEQIAADGLIILTDADAVYEHWGTPQQRAIR
QASPDELAPFAKADGAMGPKVTAVSGYVKRCGKPAWIGALSRIDDTLAGRAGTCICL