Protein Info for GFF4421 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Ureidoglycolate hydrolase (EC 3.5.3.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 100% identical to ALLA_SALTY: Ureidoglycolate lyase (allA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01483, ureidoglycolate hydrolase [EC: 3.5.3.19] (inferred from 99% identity to set:SEN0496)

MetaCyc: 85% identical to ureidoglycolate lyase (Escherichia coli K-12 substr. MG1655)
Ureidoglycolate lyase. [EC: 4.3.2.3]

Predicted SEED Role

"Ureidoglycolate hydrolase (EC 3.5.3.19)" in subsystem Allantoin Utilization (EC 3.5.3.19)

MetaCyc Pathways

allantoin degradation to glyoxylate II (5/5 steps found)
allantoin degradation to glyoxylate III (5/5 steps found)
superpathway of allantoin degradation in plants (6/8 steps found)
allantoin degradation to glyoxylate I (2/3 steps found)
superpathway of allantoin degradation in yeast (4/6 steps found)
superpathway of purines degradation in plants (10/18 steps found)

KEGG Metabolic Maps

Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.3.19 or 4.3.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (160 amino acids)

>GFF4421 Ureidoglycolate hydrolase (EC 3.5.3.19) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKLEVLPLDQKTFSAYGDVIETQEREFFHINNGLVERYHDLAKVEVLEQDRTLISINRAQ
PAAMPIVVHELERHPLGTQAFVPMNGEAFVVIVALGDDKPDLSTLRAFISNGRQGVNYHR
NVWHHPLFAWQTVTDFLTVDRGGSDNCDVESIPTHELCFA