Protein Info for GFF4396 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868
Annotation: Inosine-guanosine kinase (EC 2.7.1.73)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 94% identical to INGK_ECOL6: Inosine-guanosine kinase (gsk) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K00892, inosine kinase [EC: 2.7.1.73] (inferred from 100% identity to sec:SC0533)MetaCyc: 94% identical to inosine/guanosine kinase (Escherichia coli K-12 substr. MG1655)
Inosine kinase. [EC: 2.7.1.73]; 2.7.1.73 [EC: 2.7.1.73]
Predicted SEED Role
"Inosine-guanosine kinase (EC 2.7.1.73)" in subsystem Purine conversions (EC 2.7.1.73)
MetaCyc Pathways
- adenine and adenosine salvage V (3/3 steps found)
- superpathway of guanine and guanosine salvage (3/3 steps found)
- guanine and guanosine salvage III (1/1 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.73
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (434 amino acids)
>GFF4396 Inosine-guanosine kinase (EC 2.7.1.73) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868) MKFPGKRKSKHYFPVNARDPLLQQIQPEQETNASWVVGIDQTLVDIEAKVDDDFITRYGL SAGHSLVIEDEVAEKLYQELTRENLITHQFAGGTIGNTMHNYSVLADDRSVLLGVMCSNI EIGSYAYRYLCNTSSRTDLNYLQAVDGPIGRCFTLIGESGERTFAISPGHMNQLRAESIP EAVIAGASALVLTSYLVRCKPGEPMPDATMKAIEYAKKHNVPVVMTLGTKFVIADNPQWW QAFLKENVSILAMNEEEAEALTGENDPLLAADKALDWVDLVLCTAGPIGLYMAGFTEEEA KRKTQHPLLPGAIAEFNQYEFSRAMRHKDCINPLRVYSHIAPYMGGPEKIMNTNGAGDGA LAALLHDITANSYHRSNVPNSSKHKFTWLTYSSLAQVCKYANRVSYQVLNQHSPRLTRGL PEREDSLEESYWDR