Protein Info for GFF4395 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Acetyl esterase (EC 3.1.1.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 323 PF10340: Say1_Mug180" amino acids 80 to 237 (158 residues), 43.3 bits, see alignment E=3.5e-15 PF20434: BD-FAE" amino acids 80 to 271 (192 residues), 61.3 bits, see alignment E=1.5e-20 PF07859: Abhydrolase_3" amino acids 88 to 295 (208 residues), 191.7 bits, see alignment E=2.1e-60

Best Hits

Swiss-Prot: 100% identical to AES_SALTY: Acetyl esterase (aes) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01066, esterase / lipase [EC: 3.1.1.-] (inferred from 99% identity to sei:SPC_0505)

MetaCyc: 75% identical to acetylesterase (Escherichia coli K-12 substr. MG1655)
Acetylesterase. [EC: 3.1.1.6]

Predicted SEED Role

"Acetyl esterase (EC 3.1.1.-)" (EC 3.1.1.-)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.1.-

Use Curated BLAST to search for 3.1.1.- or 3.1.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (323 amino acids)

>GFF4395 Acetyl esterase (EC 3.1.1.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKPENKIPVLTRLSDEMTAVVNFQQPGLPPWPADGDIETQRQYYLLERRFWNADAPSMTT
RTCAVPTPYGDVTTRLYSPQPTSQATLYYLHGGGFILGNLDTHDRIMRLLARYTGCTVIG
IDYSLSPQARYPQAIEETVAVCSYFSQHADEYSLNVEKIGFAGDSAGAMLALASALWLRD
KHIRCGNVIAILLWYGLYGLQDSVSRRLFGGAWDGLTREDLDMYEKAYLRNDEDRESPWY
CLFNNDLTRDVPPCFIASAEFDPLIDDSRLLHQTLQAHQQPCEYKMYPGTLHAFLHYSRM
MTIADDALQDGARFFMARMKTPR