Protein Info for GFF437 in Variovorax sp. SCN45

Annotation: Antiholin-like protein LrgA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 140 transmembrane" amino acids 24 to 45 (22 residues), see Phobius details amino acids 51 to 69 (19 residues), see Phobius details amino acids 80 to 99 (20 residues), see Phobius details amino acids 106 to 130 (25 residues), see Phobius details PF03788: LrgA" amino acids 35 to 127 (93 residues), 83.9 bits, see alignment E=3.1e-28

Best Hits

KEGG orthology group: None (inferred from 93% identity to vpe:Varpa_3366)

Predicted SEED Role

"Antiholin-like protein LrgA" in subsystem Murein hydrolase regulation and cell death

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (140 amino acids)

>GFF437 Antiholin-like protein LrgA (Variovorax sp. SCN45)
MDKGGVFPRTFALSAHPNKNTKTMLYAITTLFLCQLAGELLVQWLGLPIPGPLIGMVLLF
IGLLVRGGVPQVLTDTSGHLLRNLMLLFIPAVAGVMLHFERVGREWLPFLAAGIVGAAFT
MTVTALTFRWMIRVTGKDAE