Protein Info for GFF4346 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: GTP-binding protein TypA/BipA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 608 PF00009: GTP_EFTU" amino acids 3 to 200 (198 residues), 193.1 bits, see alignment E=9e-61 TIGR00231: small GTP-binding protein domain" amino acids 4 to 170 (167 residues), 89.2 bits, see alignment E=2.5e-29 TIGR01394: GTP-binding protein TypA/BipA" amino acids 5 to 603 (599 residues), 908.7 bits, see alignment E=1.4e-277 PF01926: MMR_HSR1" amino acids 8 to 129 (122 residues), 23.5 bits, see alignment E=1.3e-08 PF03144: GTP_EFTU_D2" amino acids 223 to 294 (72 residues), 35.6 bits, see alignment E=2.6e-12 PF00679: EFG_C" amino acids 402 to 487 (86 residues), 72.9 bits, see alignment E=4.4e-24 PF21018: BipA_C" amino acids 489 to 597 (109 residues), 148.7 bits, see alignment E=1.2e-47

Best Hits

Swiss-Prot: 58% identical to TYPA_ECOLI: GTP-binding protein TypA/BipA (typA) from Escherichia coli (strain K12)

KEGG orthology group: K06207, GTP-binding protein (inferred from 92% identity to vap:Vapar_2751)

Predicted SEED Role

"GTP-binding protein TypA/BipA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (608 amino acids)

>GFF4346 GTP-binding protein TypA/BipA (Hydrogenophaga sp. GW460-11-11-14-LB1)
MSKQIRNIAIIAHVDHGKTTMVDQLLRQSGTFAEHEKVVDTVMDNNAIERERGITILAKN
CAVSWEGTHINIVDTPGHADFGGEVERALSMVDGVVLLIDAQEGPMPQTRFVTKKALALG
LKPIVVVNKVDKPGANPDKVINAAFDLFDKLGANDEQLDFPVVYASGINGWTSLVEGAPG
EQWGPDMSALFNTVLKHVPSQKGDPSAPLQLQISALDFSTFVGRIGVGRVSAGVVKPGMD
VAVMEGADGKTIKGRVNQVLTFQGLDRVQVTEAGPGDIVLINGIADIGIGVTITDPLNPA
PLPMLKIDEPTLTMNFCVNTSPLAGREGKYVTSRQVWDRLQKELQSNVALRVKETSEDGI
FEVMGRGELHLTILLENMRREGYELAVSKPRVVFREINGERHEPIEMVTADIEEQHQGGV
MQALGERKGELVNMEPDGRGRVRLEYRIPARGLIGFTNEFLNLTRGSGLIANIFDGYEPH
KGDIASRKNGVLISMDDGEIFTYALGKLDDRGRMFVRAGDPVYEGMIVGIHNRDNDLVVN
ATRTKQLTNFRVSGKEDAIKITPPIECTLEYGVEFIEDDELVEITPKSIRLRKRHLKEHD
RKRASREG