Protein Info for GFF4346 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Cytochrome O ubiquinol oxidase subunit II (EC 1.10.3.-)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01433: ubiquinol oxidase, subunit II
  • amino acids 4 to 230 (227 residues), 409.2 bits, E=1.9e-127
• PF00116: COX2
  • amino acids 140 to 209 (70 residues), 24.3 bits, E=2.5e-09
• PF06481: COX_ARM
  • amino acids 230 to 276 (47 residues), 65.5 bits, 3.2e-22

Best Hits

Swiss-Prot: 96% identical to CYOA_ECOL6: Cytochrome bo(3) ubiquinol oxidase subunit 2 (cyoA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02297, cytochrome o ubiquinol oxidase subunit II [EC: 1.10.3.-] (inferred from 99% identity to seh:SeHA_C0545)

MetaCyc: 96% identical to cytochrome bo3 subunit 2 (Escherichia coli K-12 substr. MG1655)
RXN-21817 [EC: 7.1.1.3]

Predicted SEED Role

"Cytochrome O ubiquinol oxidase subunit II (EC 1.10.3.-)" in subsystem Terminal cytochrome O ubiquinol oxidase or Terminal cytochrome oxidases (EC 1.10.3.-)

MetaCyc Pathways

• D-lactate to cytochrome bo oxidase electron transfer (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer I (1/2 steps found)
• NADH to cytochrome bo oxidase electron transfer II (1/2 steps found)
• glycerol-3-phosphate to cytochrome bo oxidase electron transfer (1/2 steps found)
• proline to cytochrome bo oxidase electron transfer (1/2 steps found)
• pyruvate to cytochrome bo oxidase electron transfer (1/2 steps found)
• succinate to cytochrome bo oxidase electron transfer (1/2 steps found)

Isozymes

Compare fitness of predicted isozymes for: 1.10.3.-

Use Curated BLAST to search for 1.10.3.- or 7.1.1.3

Protein Sequence (309 amino acids)

>GFF4346 Cytochrome O ubiquinol oxidase subunit II (EC 1.10.3.-) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
LGWLSLIAGTALLSGCNSALLDPKGQIGLEQRSLILTAFGLMLIVVIPAILMAVGFAWKY
RASNKDAKYSPNWSHSNKVEAVVWTVPILIIIFLAVLTWKTTHALEPSKPLAHDEKPITI
EVVSMDWKWFFIYPEQGIATVNEIAFPANTPVYFKVTSNSVMNSFFIPRLGSQIYAMAGM
QTRLHLIANEPGTYDGISASYSGPGFSGMKFKAIATKDRAEFDQWVAKAKQSPNTMNDMA
AFEKVAMPSEYNKVEYFSSVKPDLFKDVINKFMGHGKSMDMTQPEGEHSSHEGMEGMDMS
HAESANSKG