Protein Info for GFF4337 in Sphingobium sp. HT1-2

Annotation: Cytochrome c oxidase (cbb3-type) subunit CcoN (EC 1.9.3.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 553 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details transmembrane" amino acids 35 to 54 (20 residues), see Phobius details amino acids 75 to 102 (28 residues), see Phobius details amino acids 122 to 142 (21 residues), see Phobius details amino acids 154 to 177 (24 residues), see Phobius details amino acids 190 to 211 (22 residues), see Phobius details amino acids 223 to 245 (23 residues), see Phobius details amino acids 267 to 288 (22 residues), see Phobius details amino acids 299 to 317 (19 residues), see Phobius details amino acids 336 to 357 (22 residues), see Phobius details amino acids 369 to 390 (22 residues), see Phobius details amino acids 409 to 429 (21 residues), see Phobius details amino acids 448 to 468 (21 residues), see Phobius details amino acids 497 to 522 (26 residues), see Phobius details TIGR00780: cytochrome c oxidase, cbb3-type, subunit I" amino acids 71 to 530 (460 residues), 766.5 bits, see alignment E=5.5e-235 PF00115: COX1" amino acids 76 to 506 (431 residues), 397.1 bits, see alignment E=5.2e-123

Best Hits

Swiss-Prot: 78% identical to FIXN_RHIME: Cytochrome c oxidase subunit 1 homolog, bacteroid (fixN) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K00404, cb-type cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 82% identity to npp:PP1Y_AT1708)

MetaCyc: 71% identical to cytochrome cbb3 oxidase subunit I (Rhodobacter capsulatus)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase subunit CcoN (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (553 amino acids)

>GFF4337 Cytochrome c oxidase (cbb3-type) subunit CcoN (EC 1.9.3.1) (Sphingobium sp. HT1-2)
MDELLFKVGGWLLLAILALFACALALDSGFSVHMAIASATALLIAWITMYKADFQVLSGF
KPATMPDVTRYDDDLIRLGVIATLFWGVVGFLVGVVIATQMVVPTLNLEPWFSFGRMRPL
HTSAVIFAFGGNALIATSFYVVQRTCRARLAFPALARFVFWGYQFFIVLAATGYLMGVTA
SREYAEPEWYVDLWLTIVWVAYFVVFVGTLLRRTEPHIYVANWFYLSFIITIAMLHIVNN
LAVPASLFGSKSYSAFAGVQDALTQWWYGHNAVGFFLTAGFLAMMYYFVPKQAERPIYSY
RLSIIHFWSLIFLYIWAGPHHLHYTALPDWAQTLGMVFSVVLWMPSWGGMINGLMTLNGA
WDKIRTDPIIRMMVFALAFYGMATFEGPMLSIKAVNSLSHYTEWTIGHVHSGALGWNGMI
TFAALYYLVPRLWGRERLYSLRMVNWHFWLATLGLVLYAAALWVAGITQGLMAREYGSDG
YLVYAFAEIVAAMKPYYAIRVLGGLLYLLGALIMVYNVWMTILGRLRKEAPMSSAAYNPE
ADRPIVPAATPAE