Protein Info for GFF4333 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF03709: OKR_DC_1_N
  • amino acids 21 to 143 (123 residues), 114.1 bits, E=6.2e-37
• PF01276: OKR_DC_1
  • amino acids 149 to 590 (442 residues), 482.1 bits, E=2e-148
• PF03711: OKR_DC_1_C
  • amino acids 617 to 741 (125 residues), 159.5 bits, E=8.1e-51

Best Hits

KEGG orthology group: K01582, lysine decarboxylase [EC: 4.1.1.18] (inferred from 87% identity to aav:Aave_3257)

Predicted SEED Role

"Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)" (EC 4.1.1.17, EC 4.1.1.18, EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (15/17 steps found)
• superpathway of putrescine biosynthesis (4/4 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• putrescine biosynthesis III (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• cadaverine biosynthesis (1/1 steps found)
• superpathway of polyamine biosynthesis I (6/8 steps found)
• L-lysine degradation X (4/6 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (1/3 steps found)
• aminopropylcadaverine biosynthesis (1/3 steps found)
• putrescine biosynthesis II (1/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (8/13 steps found)
• superpathway of ornithine degradation (4/8 steps found)
• superpathway of polyamine biosynthesis II (4/8 steps found)
• spermidine biosynthesis III (1/4 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (6/11 steps found)
• L-lysine degradation I (3/7 steps found)
• bisucaberin biosynthesis (1/5 steps found)
• desferrioxamine B biosynthesis (1/5 steps found)
• desferrioxamine E biosynthesis (1/5 steps found)
• lupanine biosynthesis (1/5 steps found)
• superpathway of hyoscyamine (atropine) and scopolamine biosynthesis (4/16 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Alkaloid biosynthesis II
• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Glutathione metabolism
• Lysine degradation
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.1.17 or 4.1.1.18 or 4.1.1.19

Protein Sequence (758 amino acids)

>GFF4333 Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MKFRFPIVIIDEDFRSENTSGLGIRALAQAIEVEGFEVVGVTSYGDMSQFAQQQSRASAF
ILSIDDEEFSHGDDIDPVVLNLRSFIDEVRRKNADVPIYIYGETKTSRHLPNDVLRELHG
FIHMFEDTPEFVARHIIREAKSYLEGIQPPFFKALLDYAEDGSYSWHCPGHSGGVAFLKS
PVGQMFHQFFGENMLRADVCNAVEELGQLLDHNGAIGASERNAARIFNADHCFFVTNGTS
TSNKMVWHHTVAPGDVVVVDRNCHKSILHSIIMTGAIPVFLKPTRNHYGIIGPIPQSEFE
IEAIQAKIRANPLLAGVDAATVKPRVLTLTQSTYDGVLYNTEAIKQMLDGYVANLHFDEA
WLPHAAFHPFYGNFHAMGKKRARPMESVVYATQSIHKLLAGISQASHVLVQDSQNVKLDR
HLFNEAYLMHTSTSPQYAIIASCDVAAAMMEPPGGRALVEESIFEALDFRRAMRKVEAEF
GEDDWWFKVWGPDDLADEGMGEAGDWVLKQKDVSFNDKDWHGFGDMAPGFNMLDPIKATI
VTPGLNLDGRFEANGIPASIVTKFLAEHGVVVEKTGLYSFFIMFTIGITKGRWNTLLTAL
QQFKDDYAKNQPMWRILPEFCQKHPRYEQMGLRDLCQHVHELYARYDIARLTTEMYLSDL
TPAMKPSDAFAHIAQRTTERVPIDDLEGRITTSLVTPYPPGIPLLIPGEVFNKKIVDYLK
FAREFNLQCPGFETDIHGLVEVVGDDGRKSYFADCVKA