Protein Info for GFF4331 in Sphingobium sp. HT1-2

Annotation: Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 704 transmembrane" amino acids 86 to 107 (22 residues), see Phobius details amino acids 118 to 135 (18 residues), see Phobius details amino acids 155 to 173 (19 residues), see Phobius details amino acids 179 to 197 (19 residues), see Phobius details amino acids 334 to 355 (22 residues), see Phobius details amino acids 361 to 388 (28 residues), see Phobius details amino acids 657 to 674 (18 residues), see Phobius details amino acids 679 to 698 (20 residues), see Phobius details PF00403: HMA" amino acids 7 to 54 (48 residues), 37.9 bits, see alignment 2.8e-13 TIGR01511: copper-translocating P-type ATPase" amino acids 134 to 700 (567 residues), 489.7 bits, see alignment E=2.7e-150 TIGR01525: heavy metal translocating P-type ATPase" amino acids 153 to 699 (547 residues), 463.2 bits, see alignment E=3.1e-142 TIGR01512: cadmium-translocating P-type ATPase" amino acids 179 to 700 (522 residues), 332.3 bits, see alignment E=1e-102 TIGR01494: HAD ATPase, P-type, family IC" amino acids 186 to 685 (500 residues), 211.1 bits, see alignment E=4.4e-66 PF00122: E1-E2_ATPase" amino acids 220 to 395 (176 residues), 142.4 bits, see alignment E=1.8e-45 PF00702: Hydrolase" amino acids 413 to 611 (199 residues), 89.9 bits, see alignment E=4.3e-29

Best Hits

KEGG orthology group: None (inferred from 61% identity to sal:Sala_1670)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.4

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (704 amino acids)

>GFF4331 Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4) (Sphingobium sp. HT1-2)
VSAVTSTFSVPGLHCAGCIAKLEGGLARTDGVISARVNFTKRRVAIAHTDKLGDDHLREI
IGRIGFPAERLLGEEETRSAPESRELGIALGVAGFAAMNIMLLSVSVWSGAQGATRDLFH
WLSALIALPTVAYAGRPFFRSAWGALRHGRTNMDVPISIGVTMACAASLYETINSGPHAY
FDGAVMLLFFLLAGRFLDSVMRVRAEDGVAALQRQRAPRGLVVGKDGVAEWRNAEEIAPG
MTLLVAAGETFAADGVIVSGASSIDRQLVTGESAPENVGIGDAVLAGTINLAAPLTVKVS
AAGEGTAIAGIARLMEAASGAKSRYVRLADRAARYYAPAVHVLAALSLVGWLIAGAGLHQ
AVLIAVAVLIITCPCALGLAVPVAQVVAAGSLMRRGVLIRDGAGLERLAEANVALFDKTG
TLTLGRPRLIDDGNLSPDERPVALALAQRSRHPLARALATALEGIEAADISDVEEAPGLG
VAAIWKGQRAFLGRIDDAGPEGGEAPGHHALTTGFRLGGGPARLLRFEDALRPDADAAIA
RLDALHMQPTIVSGDRERRVARLAVKLGMRGQGDLDPQGKLEVIARLSAQGHRVLMVGDG
LNDGPALNAAHVSMAPSSASDVGQSAADLVFLGDSLSAVPASVAAARRTMRVVKQNFAMA
IGYNVLAVPLAVAGMVTPLVAALAMSLSSIIVVGNSLRLRNAAR