Protein Info for PS417_22140 in Pseudomonas simiae WCS417

Updated annotation (from data): glucose/xylose ABC transporter, permease component 2
Rationale: Specifically important for utilization of D-glucose 6-phosphate and D-xylose. Glucokinase (PS417_22685) is important for glucose-6-phosphate utilization, which implies that it is hydrolyzed to glucose before uptake.
Original annotation: sugar ABC transporter permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 transmembrane" amino acids 23 to 45 (23 residues), see Phobius details amino acids 81 to 103 (23 residues), see Phobius details amino acids 115 to 135 (21 residues), see Phobius details amino acids 164 to 189 (26 residues), see Phobius details amino acids 210 to 235 (26 residues), see Phobius details amino acids 271 to 293 (23 residues), see Phobius details PF00528: BPD_transp_1" amino acids 94 to 290 (197 residues), 51.7 bits, see alignment E=4.6e-18

Best Hits

Swiss-Prot: 36% identical to Y1215_PYRHO: Probable ABC transporter permease protein PH1215 (PH1215) from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)

KEGG orthology group: K02025, multiple sugar transport system permease protein (inferred from 98% identity to pfs:PFLU4845)

Predicted SEED Role

"Glucose ABC transport system, inner membrane component 1"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U818 at UniProt or InterPro

Protein Sequence (302 amino acids)

>PS417_22140 glucose/xylose ABC transporter, permease component 2 (Pseudomonas simiae WCS417)
MSSVAVFSKASPFDALQRWLPKLVLAPSMFIVLVGFYGYILWTFVLSFTNSTFLPTYKWA
GLAQYARLFDNDRWWVASKNLAVFGGMFIGITLVIGVTLAIFLDQKIRREGFIRTIYLYP
MALSMIVTGTAWKWLLNPGMGLDKLLRDWGWEGFRLDWLIDPDRVVYCLVIAAVWQASGF
IMAMFLAGLRGVDQSIVRAAQIDGASMPRIYWSVVLPSLRPVFFSAVMILAHIAIKSFDL
VAAMTAGGPGYSSDLPAMFMYSFTFSRGQMGMGSASAILMLGAILAIIVPYLYSELRTKR
ND