Protein Info for GFF4313 in Variovorax sp. SCN45
Annotation: 2-dehydropantoate 2-reductase (EC 1.1.1.169)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 49% identical to PANE_RHILO: Putative 2-dehydropantoate 2-reductase (mll6982) from Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
KEGG orthology group: K00077, 2-dehydropantoate 2-reductase [EC: 1.1.1.169] (inferred from 47% identity to rsk:RSKD131_2957)Predicted SEED Role
"2-dehydropantoate 2-reductase (EC 1.1.1.169)" in subsystem Coenzyme A Biosynthesis (EC 1.1.1.169)
MetaCyc Pathways
- superpathway of coenzyme A biosynthesis II (plants) (9/10 steps found)
- superpathway of coenzyme A biosynthesis I (bacteria) (8/9 steps found)
- phosphopantothenate biosynthesis I (4/4 steps found)
- phosphopantothenate biosynthesis III (archaea) (2/4 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.169
Use Curated BLAST to search for 1.1.1.169
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (334 amino acids)
>GFF4313 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Variovorax sp. SCN45) MKICIYGAGAIGGYLATHLAQADGVQVSVVARGAHLAAIRANGLAVESPRGTLRARVQAT DDPRTLGPQDYVVLALKSHQVADALGGVQALLGPHTAVLPPTTGIPYWYFHGLPGALRDR QIERLDPQGLQWRAMAPERVIGCVYWVASEVTAPGVIHHDGALSRFPVGEPDGASSERVL RFADAMKAGGLDAPVVPDIRGWIWAKMISSLCWNPVATLTLGTLSEMNARPEVVTIVRAM MTEADALAQRLGVERTPIGIEQRIAAARNAGDHKMSMLQDLERGRPLELGVLFDSIEAMR ELAQTPTPTIDTVYALLRLRAEKQTTQKAAEPTA