Protein Info for GFF4311 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 452 PF13458: Peripla_BP_6" amino acids 100 to 443 (344 residues), 200 bits, see alignment E=1.4e-62 PF01094: ANF_receptor" amino acids 121 to 442 (322 residues), 111.1 bits, see alignment E=9.5e-36 PF13433: Peripla_BP_5" amino acids 230 to 427 (198 residues), 30.4 bits, see alignment E=3.3e-11

Best Hits

KEGG orthology group: K01999, branched-chain amino acid transport system substrate-binding protein (inferred from 77% identity to lch:Lcho_2592)

Predicted SEED Role

"Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (452 amino acids)

>GFF4311 Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MRRSYGAFNGVMCLWENPRSIPQVLRDAKSGGFLEYLYGRGEIKFPPHSNFHPFPRKTMQ
LNTKLAVIAAAVALAACGKKEEAAPAAAPAAAPAPAAQVIKIGHVGPTSGAIAHLGKDNE
NGARMAIEELNAAGLTIGGNAVKFELLAEDDAADPKQGTAAATKLVDAKVAGVIGHLNSG
TTIPASQIYNDAGIPQISPSATNPKYTRQGYAGAFRVVADDVHLGGTLGKYAVETLKAKS
VAVIDDRTAYGQGVADEFEKGVAAAGGKVVGREFTNDKATDFNAILTTLKAKKPDVVFFG
GMDAVAGPMLKQMKQLGINAKFMGGDGICSTELPKLAADGLADDQVFCAEAGGVEGEQKA
GMDKFRTDFKAKFNADVQVYAPYVYDATKVLVNAMVTAGSADPKVYLPALKATNYKGVTG
NIAFDEKGDIKNGALTLMTYKGGNRTTLAVIR