Protein Info for GFF4293 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01077: NIR_SIR
  • amino acids 140 to 288 (149 residues), 129.1 bits, E=1e-41
  • amino acids 441 to 579 (139 residues), 47.4 bits, E=1.5e-16
• PF03460: NIR_SIR_ferr
  • amino acids 376 to 425 (50 residues), 45.3 bits, 6e-16

Best Hits

KEGG orthology group: K00381, sulfite reductase (NADPH) hemoprotein beta-component [EC: 1.8.1.2] (inferred from 70% identity to del:DelCs14_2158)

Predicted SEED Role

"Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2)" in subsystem Cysteine Biosynthesis (EC 1.8.1.2)

MetaCyc Pathways

• superpathway of L-methionine biosynthesis (by sulfhydrylation) (11/12 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (8/9 steps found)
• assimilatory sulfate reduction III (3/3 steps found)
• assimilatory sulfate reduction I (3/4 steps found)
• superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

• Sulfur metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.2

Use Curated BLAST to search for 1.8.1.2

Protein Sequence (591 amino acids)

>GFF4293 Sulfite reductase [NADPH] hemoprotein beta-component (EC 1.8.1.2) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MYQYSDFDRQFVHLRAAQYRDQLTRWQAGTLGDDEFKPLRLQNGWYVQRFAPMLRVAVPY
GEISSPQLRVLAKIARDFDHKEEHDVSKANAGLSEVPTLPDRCGHFTTRQNVQYNWIPLS
RSADVMDLLASVGLHGIQTSGNCIRNITTDALAGIAIDEVADPRPFAEILRQWSTLHPEF
AFLPRKFKVAITGAREDRAATPWHDVGLRLLRNVDGDLGFQVRVGGGMGRTPIIGSVIRE
FLPWNQILNYLEAVVRAYNRFGRRDNIYKARIKILVKAEGQAFTDQVEAEYRDILEKDGA
PHTISQAELDRVSAFFVPPQLNCDRKSADAKIAHILKAAAEDDLEFSRWLQQNVKPHQNP
DLRAVTLSFKRFGQAPGDATGEQLERAAELAERFSAGEARVTHEQNLLLPWVRCDQLPEL
WREARRLGLAKPNIGLLTDMIACPGGDFCDLANARSLPLAQAILGRYKDLDELHDLGEID
LHISGCINSCGHHHSGHIGILGVDKDGQEWYQVTLGGSDGTRLSGDATPGKVIGPSFAAS
EVPDVIEALLDTYRAQRTGQETFVNTLRRTGADPFKTAANAVRTSTARAAA