Protein Info for GFF4286 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Shikimate kinase III (EC 2.7.1.71)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00004: AAA
  • amino acids 5 to 33 (29 residues), 23.6 bits, 6e-09
• PF01202: SKI
  • amino acids 11 to 168 (158 residues), 164.5 bits, E=2.2e-52

Best Hits

Swiss-Prot: 100% identical to AROL_SALPK: Shikimate kinase 2 (aroL) from Salmonella paratyphi A (strain AKU_12601)

KEGG orthology group: K00891, shikimate kinase [EC: 2.7.1.71] (inferred from 99% identity to sew:SeSA_A0444)

MetaCyc: 74% identical to shikimate kinase 2 (Escherichia coli K-12 substr. MG1655)
Shikimate kinase. [EC: 2.7.1.71]

Predicted SEED Role

"Shikimate kinase III (EC 2.7.1.71)" in subsystem CBSS-562.2.peg.5158 SK3 including or Chorismate Synthesis or Common Pathway For Synthesis of Aromatic Compounds (DAHP synthase to chorismate) (EC 2.7.1.71)

MetaCyc Pathways

• superpathway of chorismate metabolism (54/59 steps found)
• superpathway of aromatic amino acid biosynthesis (18/18 steps found)
• superpathway of L-tryptophan biosynthesis (13/13 steps found)
• superpathway of L-phenylalanine biosynthesis (10/10 steps found)
• superpathway of L-tyrosine biosynthesis (10/10 steps found)
• chorismate biosynthesis I (7/7 steps found)
• chorismate biosynthesis from 3-dehydroquinate (5/5 steps found)
• chorismate biosynthesis II (archaea) (8/12 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from shikimate pathway
• Biosynthesis of phenylpropanoids
• Biosynthesis of plant hormones
• Phenylalanine, tyrosine and tryptophan biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.71

Use Curated BLAST to search for 2.7.1.71

Protein Sequence (181 amino acids)

>GFF4286 Shikimate kinase III (EC 2.7.1.71) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MMQPLYLVGPRGCGKTTIGMALAQATGFRFADTDRWLQSHVQMSVADIVEKEGWGGFRAR
ETAALEAVSAPSTVVATGGGIILTEYNRRYMHRVGVVIYLCAPVSTLVNRLEAEPEADLR
PTLTGKPLSEEVREVLEQRDALYRETAHYIIDATKAPAQVVSEIIAALPPSTQRLQGDVY
T