Protein Info for GFF4278 in Xanthobacter sp. DMC5

Annotation: hypothetical protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 904 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 276 to 298 (23 residues), see Phobius details PF13188: PAS_8" amino acids 315 to 359 (45 residues), 19.3 bits, see alignment 1.7e-07 PF12860: PAS_7" amino acids 319 to 431 (113 residues), 74 bits, see alignment E=2.3e-24 TIGR00254: diguanylate cyclase (GGDEF) domain" amino acids 466 to 628 (163 residues), 125.6 bits, see alignment E=8e-41 PF00990: GGDEF" amino acids 468 to 623 (156 residues), 147 bits, see alignment E=8.8e-47 PF00563: EAL" amino acids 645 to 876 (232 residues), 223.6 bits, see alignment E=4.8e-70

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (904 amino acids)

>GFF4278 hypothetical protein (Xanthobacter sp. DMC5)
MTPTMIWHRLKLSVIAGTIVILGLLAVGTLLLAHRSLVTTRHAAEAELQRSAQGVENALN
RQLLQIHGALAAIRPMFAAAGVTASSPAANELLRGFNLQTIAYRDMMLVAPDGAILASAR
PRGALRTLPVATQPTSIQPASMVGPVESPVNGDWSLYAVRAVPGWGGVVAVADVPVLSLM
KILAETGLAPGTRIRIERPTGQLVASLPHDELAIGEWRHGALGTRPPDGKAFVAANDKGE
PELAVVRSSLPGDLRVILTTDLADALAPWRRFRDRLAAAAALGGTLVAAFAGALLIALRQ
REKVDSERARATAVLANAVEAMSDGFALWDGDDRLVACNQRYREMFAITAPFLIPGARFQ
DIMRASTHAQQLPLPGPVTEEAVAERERWHRPENSPVERQMSTGRWVLMTDRRTADGGVV
AIRTDITALKAVQAELAEANLRATEAAAEAQRQNMVLIEREGRIRFLAHHDDLTGLPNRV
VFRERIGKSLHQAAELGQKMALLYLDLDRFKDVNDTLGHPVGDALLRTVAARLTNCVQAP
GAVARLSGDEFAIISIGSQQPEAATELAGRIIALLGEPYSALGHTISVSVSVGIAVAEAA
WTDADTLLKQADLALYRAKAWGRGTLCVFEPEMDVHLRARLEMEQDLRQALAQGQFELAY
QPIFSVVTGALTGFEALLRWNHPRRGLVDPSIFVPLTEDSRSIVEIGAFAMRQAVADIAT
LPGDLKVAVNLSPVQLAFGDIIGTVEAALRDSGLPPERLECEITETALFESEQTSLAVLQ
RLRDVGVRIVLDDFGTGYSSLSRLRLLPIDKIKIDRSFVLDATEGSASAAIIEAVTVLTG
RLGIATVAEGIETEEQWALLARTSCAEAQGFLLGRPLPIAEAAALARAGAGVPVALARRF
SPPA