Protein Info for GFF4274 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Diacylglycerol kinase (EC 2.7.1.107)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01219: DAGK_prokar
  • amino acids 24 to 123 (100 residues), 110.5 bits, E=1.6e-36

Best Hits

Swiss-Prot: 48% identical to KDGL_ECOL6: Diacylglycerol kinase (dgkA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K00901, diacylglycerol kinase [EC: 2.7.1.107] (inferred from 73% identity to pol:Bpro_2312)

MetaCyc: 48% identical to diacylglycerol kinase (Escherichia coli K-12 substr. MG1655)
Diacylglycerol kinase. [EC: 2.7.1.107]

Predicted SEED Role

"Diacylglycerol kinase (EC 2.7.1.107)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.1.107)

MetaCyc Pathways

• diacylglycerol and triacylglycerol biosynthesis (3/7 steps found)
• phosphatidate metabolism, as a signaling molecule (1/5 steps found)
• type I lipoteichoic acid biosynthesis (S. aureus) (5/17 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glycerophospholipid metabolism
• Phosphatidylinositol signaling system

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.107

Use Curated BLAST to search for 2.7.1.107

Protein Sequence (129 amino acids)

>GFF4274 Diacylglycerol kinase (EC 2.7.1.107) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNDQEPVDAQKRRTGLTRMAHAFRYSLAGLRSGWGETAFRQEALASMVMIPAAFWIGRTW
VETALLVASVVLVMVVELLNTGIETAIDRIGPEWHDLSKRAKDMGSAAVLLSLVLCAGIW
IAALWAHWA