Protein Info for GFF4267 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Pyrophosphate-energized proton pump (EC 3.6.1.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 687 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details amino acids 57 to 75 (19 residues), see Phobius details amino acids 81 to 102 (22 residues), see Phobius details amino acids 123 to 149 (27 residues), see Phobius details amino acids 164 to 184 (21 residues), see Phobius details amino acids 240 to 258 (19 residues), see Phobius details amino acids 264 to 284 (21 residues), see Phobius details amino acids 296 to 320 (25 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 392 to 422 (31 residues), see Phobius details amino acids 470 to 489 (20 residues), see Phobius details amino acids 508 to 528 (21 residues), see Phobius details amino acids 576 to 595 (20 residues), see Phobius details amino acids 602 to 624 (23 residues), see Phobius details amino acids 667 to 686 (20 residues), see Phobius details TIGR01104: V-type H(+)-translocating pyrophosphatase" amino acids 8 to 683 (676 residues), 899.3 bits, see alignment E=1e-274 PF03030: H_PPase" amino acids 15 to 679 (665 residues), 924.2 bits, see alignment E=2.5e-282

Best Hits

Swiss-Prot: 81% identical to HPPA_RHOPL: K(+)-insensitive pyrophosphate-energized proton pump (hppA) from Rhodopseudomonas palustris

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 90% identity to pna:Pnap_1701)

Predicted SEED Role

"Pyrophosphate-energized proton pump (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (687 amino acids)

>GFF4267 Pyrophosphate-energized proton pump (EC 3.6.1.1) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MVGQSALIFALVCGLVAVIYGFWSRSWILSQDAGNARMQEIAGAIQTGAAAYLARQYKTI
GIVGVVLAILIGVFLDGPTAIGFVLGAVLSGACGFIGMNISVRANVRTAQAATKGIGPAL
DVAFRGGAITGMLVVGLGLLGVTGFFWFLVGNGNLTPAANLAKLLNPLIGFAFGSSLISI
FARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADLFETY
AVTLIATMVLGALMVAAAPMQAVLYPLVLGGVSILASIVGCFFVKASPGMKNVMPALYKG
LAIAGVLSLIAFWFVTGWIMPDNAITATGSQLRLFGACAVGLVLTAALVWITEFYTGTQY
SPVKHIAQASTTGHGTNIIAGLGVSMRSTAWPVLFVCVGIVASYTLAGLYGIAIAATAML
SMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAIGSAGL
AALVLFADYTHKLETYGHQIKFDLSDPMVIIGLFIGGMIPYLFGAMAMEAVGRAAGSVVV
EVRRQFKEIPGIMEGTAKPEYGKAVDMLTTAAIKEMVIPSLLPVVVPILVGVFLGPKALG
GLLMGTIVTGLFVAISMCTGGGAWDNAKKYIEDGHHGGKGSEAHKAAVTGDTVGDPYKDT
AGPAVNPLIKIINIVALLIVPLLPLAA