Protein Info for GFF4261 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: RND multidrug efflux transporter; Acriflavin resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1028 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 332 to 352 (21 residues), see Phobius details amino acids 359 to 381 (23 residues), see Phobius details amino acids 387 to 410 (24 residues), see Phobius details amino acids 430 to 450 (21 residues), see Phobius details amino acids 462 to 482 (21 residues), see Phobius details amino acids 523 to 542 (20 residues), see Phobius details amino acids 845 to 864 (20 residues), see Phobius details amino acids 874 to 893 (20 residues), see Phobius details amino acids 901 to 924 (24 residues), see Phobius details amino acids 947 to 967 (21 residues), see Phobius details amino acids 977 to 1003 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 5 to 1003 (999 residues), 1016.9 bits, see alignment E=0 PF03176: MMPL" amino acids 288 to 491 (204 residues), 51.6 bits, see alignment E=1.1e-17 amino acids 820 to 1014 (195 residues), 28 bits, see alignment E=1.7e-10

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 70% identity to lch:Lcho_1968)

Predicted SEED Role

"RND multidrug efflux transporter; Acriflavin resistance protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1028 amino acids)

>GFF4261 RND multidrug efflux transporter; Acriflavin resistance protein (Hydrogenophaga sp. GW460-11-11-14-LB1)
MQLPEISIRRPVFASVLSLLILLVGIVSFNGLTVREYPKIDEPTVTVSTRFGGASSEVIE
SQVTKPLEDSLAGIEGLDVITSISRQEQSQITVRFKLERDPDSAAADVRDKVSRVRQRLP
QDVDEPVIAKVEADASPVIWLALTSDTHSALQLSDFANRLAKPVLQTAPGAAEVRVYGER
RYSMRIWMDPDRLAAYALTVQDVEDALRRSNLEVPAGRIESTLREFNVTAATDLQTPAQF
AAVAIRTINGQTIRIGDVARVVQAPQDERTSVRLNGRDAVSLGVIRQATANPLELSAAVR
QMLEKVKQDLPAGVNVDVANDNSVFIDRSIKAVYTTIAEAVVLVALVIFVFLRTLRASII
PLMTIPVSLIGAFALMAMFGFSINTLTLLALVLAIGLVVDDAIVMLENIYRHIEEGMKPF
DAAIQGAREIGFAIVAMTLTLAAVYAPLAFTPGRTGRLFAEFALALAGAVVVSGFVALTL
SPMLCSKLLRHNPNPGRFDRGMERVLNAVTRGFSRALGASLRVRWLVVAVMAGSALASAW
MLQTMRQELAPIEDRGVILANINGPDGATLAYTRKYAEAIENIAQDYPEFDRIFVNVGNP
SVAQGVVFMRALPWEERERSTQRIAREITPRLASLPGISAFPITPPSLGQGFRERPINYV
IVTSDSYENLAQTVRRFQDELSKNPGLVQIDTDLRLNKPEIRMDVDRERAADMGVNVDAI
ARTVETMLGGRIVTRYKRDGEQYDVVVQTVSGNRSTPEDIDRLFVRGRNDAMIPLASLVK
ISEVVVPRELNHFGQRRSASLTANLAPDYALGEALQFMDKTAREVLPAGYTTDLNGQSRE
FRNASGSLAIVFALSLLFIYLVLAAQFESFVDPFIIMLSVPLSMMGALLALKLTGGTINV
FSQIGLITLVGLITKHGILIVEFANQLRDQGLEKFEAVRQSAALRLRPILMTTGAMVLGA
IPLALASGAGAESRQQIGWVIVGGMSVGTLLTIFVVPTMYTLLSRDKSHSKAKAAQHGGH
PEAAIPAK