Protein Info for GFF4238 in Pseudomonas sp. DMC3

Annotation: Serine/threonine-protein kinase toxin HipA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 407 PF13657: Couple_hipA" amino acids 8 to 107 (100 residues), 64.8 bits, see alignment E=8.7e-22 TIGR03071: HipA N-terminal domain" amino acids 8 to 106 (99 residues), 29.5 bits, see alignment E=3.3e-11 PF07804: HipA_C" amino acids 147 to 371 (225 residues), 160.5 bits, see alignment E=4.9e-51

Best Hits

KEGG orthology group: K07154, (no description) (inferred from 82% identity to pfo:Pfl01_0205)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (407 amino acids)

>GFF4238 Serine/threonine-protein kinase toxin HipA (Pseudomonas sp. DMC3)
MTEVLDRLQVCVGGHEVGRLGRGNAGVDSVFSYRDDAIDENAVSLTMPTRLESYGCERGI
HPIFEMNLPEGALRDELMRRFSKAVRGFDDFALLGIVGPHQLGRLSITSASTIDRPPETS
LAELLVHDGAQGLFEDLLQTYGQYSGVSGVQPKVLVRDSAAAIDRLTHRGSTHLVKAFRA
EEYPELATNEFFCMRAAQLCGLDVPHFELSEHGKFLVIERFDLSDTGYLGFEDFCVLNGW
PSKAKYDGSYEGVARQIKAFVSPSLLKHALEAFFKIVALSAALKNGDAHLKNFGVLYEDC
GEHSLIRLAPAYDIITTSVYIKSDSMALLLGGSKAWPKHKMLTKFGRTACNLSEARCNQL
LHMVAHGVQEAMGEMAEYSANHPAFAEVGAAMIEQWSAGLARSLRNS