Protein Info for GFF4179 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Conjugative transfer protein TrbE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 817 PF03135: CagE_TrbE_VirB" amino acids 271 to 388 (118 residues), 42.5 bits, see alignment E=1.2e-14 PF19044: P-loop_TraG" amino acids 570 to 725 (156 residues), 32 bits, see alignment E=8.1e-12

Best Hits

KEGG orthology group: K03199, type IV secretion system protein VirB4 (inferred from 98% identity to pap:PSPA7_3703)

Predicted SEED Role

"Conjugative transfer protein TrbE" in subsystem Type 4 secretion and conjugative transfer

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (817 amino acids)

>GFF4179 Conjugative transfer protein TrbE (Hydrogenophaga sp. GW460-11-11-14-LB1)
MLNLAEYRQRPALLADWLPWAGLVAPGVVLNKDGSFQRTARFRGPDLDSATQGELIATSA
RLNNALRRMGSGWALFIEAERRPAADYPHSEFPEPLSWVVEEERRAAFEESGNHFESGYH
LTLLYLPPEESRARAAKMLYENTPTNGVDWRERLQAFVAETDRVFDLLDGVMPEIDWLDD
AQTLTYLHATISTRRYRVGVPEVPFHIDALLTDSALVGGLAPMLGDQHLRLVSVRGFPTS
TWPGILDDLNRLGFAYRWSTRFLCLDKAEAEKELSRLRRQWFAKRKNVIALLRETIFQQE
SPLVDTDANNKAADADAALQELGSDQVAFGYLTATVTVMDEDAAVADEKLRMVERVIQGR
GFVTIPETLNAVDAWLSSLPGNAYANVRQPIVSTLNLAHMMPVSAVWAGPEKNEHLDGPP
LIVTRTDGATPFRLVTHIGDVGHTLVAGPTGMGKSVLLATLAMQFRRYRGSRIFAFDMGR
SMRAAILGLGGEHYDLGTDGEIAFQPLARIDREGYRTWAAEWIEGRLLHEGVAIGPDEKA
AIWSALGSLAGAPVEQRTMTGLSVLLQSNTLRQALSPYVLGGAHGKLLDADHDRLGMADV
QCFEMEELMHSKAAVMAVLHYLFARFDERFDGAPTLLILDEAWLFLDDPVFAARIRQWLK
TLRKKNVSVIFATQSLADIKDSSIAPAIIESCASRIFLPNPQATEPQIRTIYEGFGLNRR
QIEIVATAQPKRDYYYQSRLGNRLFELDLGPAALAFAGASTPQDQRDIDRVLLDAGVPGF
AGAWLRHRGLDWAADLLPSFPGLAPGSLADQPLENLP