Protein Info for GFF4162 in Variovorax sp. SCN45

Annotation: Aldehyde dehydrogenase B (EC 1.2.1.22)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 27 to 493 (467 residues), 407.4 bits, E=3.4e-126

Best Hits

KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 54% identity to nhl:Nhal_1431)

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

• ethanol degradation II (3/3 steps found)
• ethanol degradation IV (3/3 steps found)
• methylglyoxal degradation IV (3/3 steps found)
• methylglyoxal degradation V (3/3 steps found)
• L-lactaldehyde degradation (aerobic) (2/2 steps found)
• superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
• superpathway of methylglyoxal degradation (6/8 steps found)
• phytol degradation (3/4 steps found)
• ethanol degradation III (2/3 steps found)
• hypotaurine degradation (2/3 steps found)
• mitochondrial NADPH production (yeast) (3/5 steps found)
• octane oxidation (3/5 steps found)
• fatty acid α-oxidation I (plants) (2/4 steps found)
• putrescine degradation III (2/4 steps found)
• histamine degradation (1/3 steps found)
• 3-methyl-branched fatty acid α-oxidation (3/6 steps found)
• lactate biosynthesis (archaea) (2/5 steps found)
• L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
• limonene degradation IV (anaerobic) (3/7 steps found)
• serotonin degradation (3/7 steps found)
• dopamine degradation (1/5 steps found)
• ceramide degradation by α-oxidation (2/7 steps found)
• sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
• alkane oxidation (1/6 steps found)
• L-rhamnose degradation II (2/8 steps found)
• superpathway of fucose and rhamnose degradation (4/12 steps found)
• aromatic biogenic amine degradation (bacteria) (1/8 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

• 1,2-Dichloroethane degradation
• 3-Chloroacrylic acid degradation
• Arginine and proline metabolism
• Ascorbate and aldarate metabolism
• Butanoate metabolism
• Fatty acid metabolism
• Glycerolipid metabolism
• Glycolysis / Gluconeogenesis
• Histidine metabolism
• Limonene and pinene degradation
• Lysine degradation
• Propanoate metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Urea cycle and metabolism of amino groups
• Valine, leucine and isoleucine degradation
• beta-Alanine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22, 1.2.1.3

Use Curated BLAST to search for 1.2.1.22 or 1.2.1.3

Protein Sequence (509 amino acids)

>GFF4162 Aldehyde dehydrogenase B (EC 1.2.1.22) (Variovorax sp. SCN45)
MFDTQQVLSQFQIQPVHGGACTGSGGWSATQDRQVFAAVNPADGTVTARVAGATAQDYEA
VMATAAVAHKRWRMVPAPRRGELVARIGELAEAHLDALAAVVTLDTGKSLMEAKGEVREL
IDMATLAAGQSRMLYGFTQQSQRAKHRMYDQWLPLGVVGVISAYNFPAAVWAQNGFLAAI
GGNTVVWKPSPKVPLTALALQHLSNQAMREMGFEGVFTLFIPEDNQVAELLVADPRAALI
SFTGSSAVGRKVADIVGGTLGRRYMLERSGNNGCIVDETADLKLAARSITFGAVGTTGQR
CTSTRRVIAQRTVVGELVELLKQSFAQIKVGDPRDAGTVVGPLVDAAAVGHFEAAIAEAT
EAGGRVVFGGKRIDRPGHYVEPTLITQVQPEWRCVQHETFAPIVYVMAYDTLEEAIEIHN
GVPQGLASGIHSSNLGNIELFLSAQGSDCGIAKVNMGTTGADIGAAFGGEKETGGGRTAG
SDAWKGYMRRQSVCINWGGESPWDGRIKL