Protein Info for GFF4137 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (EC 2.7.1.69)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 326 transmembrane" amino acids 157 to 173 (17 residues), see Phobius details amino acids 185 to 212 (28 residues), see Phobius details amino acids 218 to 239 (22 residues), see Phobius details amino acids 247 to 276 (30 residues), see Phobius details amino acids 302 to 325 (24 residues), see Phobius details PF03612: EIIBC-GUT_N" amino acids 4 to 179 (176 residues), 192.4 bits, see alignment E=6.6e-61 PF07663: EIIBC-GUT_C" amino acids 234 to 326 (93 residues), 152.9 bits, see alignment E=2.2e-49

Best Hits

KEGG orthology group: K02782, PTS system, glucitol/sorbitol-specific IIB component [EC: 2.7.1.69] K02783, PTS system, glucitol/sorbitol-specific IIC component (inferred from 100% identity to seh:SeHA_C2926)

Predicted SEED Role

"PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (EC 2.7.1.69)" in subsystem D-Sorbitol(D-Glucitol) and L-Sorbose Utilization (EC 2.7.1.69)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (326 amino acids)

>GFF4137 PTS system, glucitol/sorbitol-specific IIB component and second of two IIC components (EC 2.7.1.69) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNTVLIPPGPGGYGKGLWLPVASGKKVLSLTGREIHPVAIEIGALTESEVVNGFSDIPPD
NDILCVVINCAGSLRCGLYPQKGIPTINVLPTWRAGPLAQFISEDNYVSGVTIEQLVLVD
TAEAPDGEPEPVSVTAPRIITTPPPARGAEKLVRMVERTGTAVGHVIALLFAASREAVDV
SLRNVIPFMAFVSLLIALVQETALGSLIAHALTPLANSLWGLVLLSLICGIPFLSPVLGP
GAAISQVIGVMIGTQIGAGAISPAFALPALFAINVQVGCDFVPVGLSMQEAKPETIAKGV
PAFLLSRQLTGPLAVIIGWLFSLGLF