Protein Info for GFF4131 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: PTS system, glucose-specific IIC component (EC 2.7.1.69) / PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIA component (EC 2.7.1.69)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 513 signal peptide" amino acids 12 to 15 (4 residues), see Phobius details amino acids 37 to 37 (1 residues), see Phobius details transmembrane" amino acids 16 to 36 (21 residues), see Phobius details amino acids 62 to 84 (23 residues), see Phobius details amino acids 90 to 112 (23 residues), see Phobius details amino acids 127 to 150 (24 residues), see Phobius details amino acids 170 to 191 (22 residues), see Phobius details amino acids 270 to 293 (24 residues), see Phobius details amino acids 304 to 322 (19 residues), see Phobius details amino acids 328 to 349 (22 residues), see Phobius details amino acids 356 to 374 (19 residues), see Phobius details amino acids 380 to 402 (23 residues), see Phobius details TIGR02002: PTS system, glucose-specific IIBC component" amino acids 6 to 500 (495 residues), 652.9 bits, see alignment E=3.4e-200 PF02378: PTS_EIIC" amino acids 15 to 344 (330 residues), 267.1 bits, see alignment E=2e-83 TIGR00826: PTS system, glucose-like IIB component" amino acids 403 to 487 (85 residues), 59.5 bits, see alignment E=3.2e-20 PF00367: PTS_EIIB" amino acids 432 to 463 (32 residues), 35.6 bits, see alignment (E = 5e-13)

Best Hits

KEGG orthology group: K02763, PTS system, D-glucosamine-specific IIA component [EC: 2.7.1.69] K02764, PTS system, D-glucosamine-specific IIB component [EC: 2.7.1.69] K02765, PTS system, D-glucosamine-specific IIC component (inferred from 100% identity to seh:SeHA_C2932)

Predicted SEED Role

No annotation

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (513 amino acids)

>GFF4131 PTS system, glucose-specific IIC component (EC 2.7.1.69) / PTS system, glucose-specific IIB component (EC 2.7.1.69) / PTS system, glucose-specific IIA component (EC 2.7.1.69) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKRFNLLQMLQSIGRSLMIPIAMLPAAGILLAFGVSFQDPNIVASLPFLGTDGLVHVLKL
MAEAGSAIFANLPLLFAVGVAVGLSDDQGIAGLSAIAGFLIMNVTIGQFLGITPESVAQV
RDYTMVLGIPSLQTGVFGGIIIGIIAAWLYKRYYRIQLPSWLEFFSGKRFVPIVTSFAAL
FVGLVMAVVWPPVQHLINGLSNTMTVQGPGVSAFLFGFVERLLIPFGLNHVWWPTFWLQF
GEYVNKAGQVVHGDQLIFFAQLKDQVPITAGTFMAGLTPIKMFCIPAIALAIYRCASPEN
IARVKGIMLSGAITSIVCGITEPIEFSFLFVAPVLYGIHAVLAGLVFLLMEWFSVHIGLS
FSGGLIDYLFFGVLPRAPHWYMVFPVGLVMGAVYYVLFTFAIRRWNLLTPGREVEETAVA
QESEQNDLVSGIILAYGGLGNMTSIEACMSRLRIDVTDKTLVDKALLKQLGAAGVVEVGN
NIQSVFGMKSDRLKEAIRAIKAHPVSGHCEPIH