Protein Info for GFF4115 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Gamma-glutamyl phosphate reductase (EC 1.2.1.41)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 8 to 282 (275 residues), 60.6 bits, E=5.4e-21
• TIGR00407: glutamate-5-semialdehyde dehydrogenase
  • amino acids 9 to 405 (397 residues), 634.1 bits, E=4.2e-195

Best Hits

Swiss-Prot: 100% identical to PROA_SALTY: Gamma-glutamyl phosphate reductase (proA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00147, glutamate-5-semialdehyde dehydrogenase [EC: 1.2.1.41] (inferred from 100% identity to spq:SPAB_03278)

MetaCyc: 86% identical to glutamate-5-semialdehyde dehydrogenase (Escherichia coli K-12 substr. MG1655)
Glutamate-5-semialdehyde dehydrogenase. [EC: 1.2.1.41]

Predicted SEED Role

"Gamma-glutamyl phosphate reductase (EC 1.2.1.41)" in subsystem Proline Synthesis (EC 1.2.1.41)

MetaCyc Pathways

• L-proline biosynthesis I (from L-glutamate) (4/4 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• L-ornithine biosynthesis II (2/3 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• L-N^δ-acetylornithine biosynthesis (4/7 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.41

Protein Sequence (416 amino acids)

>GFF4115 Gamma-glutamyl phosphate reductase (EC 1.2.1.41) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MLEQMGIAAKAASYKLALLSSGEKNRVLEKIADELEAQMESILSANVQDVEQARANGLSE
AMLDRLALTPARLKAIADDVRQVCNLADPVGQVIDGGLLDSGLRLERRRVPLGVVGVIYE
ARPNVTVDVASLCLKTGNAVILRGGKETYRTNAATVRVIQKALKACGLPEAAVQAIDNPD
RSLVNEMLRMDKYIDMLIPRGGAGLHKLCREQSTIPVITGGIGVCHIFVDSSADIAPALK
IIVNAKTQRPSTCNTVETLLVHQDIAERFLPALSKQMAESGVTLHGDETVMQVLHGPAKL
VPLKPEELDNEFLSLDLNVVVVENMDGAIAHIREHGTQHSDAILTCDMHNAARFVNEVDS
AAVYVNASTRFTDGGQFGLGAEVAVSTQKLHARGPMGLEALTTYKWIGFGDGTIRA