Protein Info for GFF4056 in Variovorax sp. SCN45

Annotation: Copper/silver efflux RND transporter, transmembrane protein CusA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1054 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 338 to 358 (21 residues), see Phobius details amino acids 364 to 384 (21 residues), see Phobius details amino acids 390 to 411 (22 residues), see Phobius details amino acids 446 to 465 (20 residues), see Phobius details amino acids 484 to 505 (22 residues), see Phobius details amino acids 537 to 554 (18 residues), see Phobius details amino acids 873 to 891 (19 residues), see Phobius details amino acids 898 to 918 (21 residues), see Phobius details amino acids 924 to 948 (25 residues), see Phobius details amino acids 981 to 998 (18 residues), see Phobius details amino acids 1010 to 1034 (25 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1043 (1043 residues), 1372.6 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1035 (1030 residues), 783.7 bits, see alignment E=1.3e-239

Best Hits

Swiss-Prot: 64% identical to SILA_SALTM: Putative cation efflux system protein SilA (silA) from Salmonella typhimurium

KEGG orthology group: K07787, Cu(I)/Ag(I) efflux system membrane protein CusA (inferred from 75% identity to adn:Alide_2726)

MetaCyc: 67% identical to copper/silver export system RND permease (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-90; TRANS-RXN0-280

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1054 amino acids)

>GFF4056 Copper/silver efflux RND transporter, transmembrane protein CusA (Variovorax sp. SCN45)
MIAKLIRWSIANRFLVLLATAMLSAWGVYSVLRTPLDALPDLSDVQVIIRTSYPGQAPRI
VENQITYPLTTTMLSVPGAKTVRGYSFFGDSFVYVLFEDGTDLYWARSRVLEYLNQVQSR
LPAAAKASLGPDATGVGWIYQYALVDRGGTQDASQLRALQDWFLKYELKTVPNVAEVASI
GGMVRQYQVVLDPEKLAAYRIPHTKAVEAIQKANQETGGSVLELGEAEYMVRASGYLQGL
EDFRKIPLMTTDAGVSVRLGDVARIQVGPEMRRGIGELDGEGEAVGGVIVMRSGKNALET
ITAVKEKLQTLQASLPKGVEIVPTYDRSNLIERAVRNLGFKLLEEFIVVAVVCFIFLFHL
RSAFVAIVSLPIGILAAFIVMRYQGVNANIMSLGGIAIAIGAMVDAAVVMIENAHKHIEK
WKHDHPDQTLRGETHWRVIADSAAEVGPALFFSLLIITLSFIPVFTLEAQEGRMFSPLAF
TKTYAMAAAAGLSVTLIPVLMGYLIRGRIPDEKTNPLNRLLIAVYQPLLNAVLRWPKLTL
AGAAVVLVLSLWPLQHIGGEFMPRLDEGDLLYMPSALPGLSTGKAGELLQQTDRLIKTVP
EVASVYGKAGRAESATDPAPIEMFETTIQFKPREQWRAGMTQDKLVEELDRIVKVPGLTN
IWVPPIRNRIDMLATGIKSPVGVKVAGTDLATIDRITGEIERVLKDVPGVSSALAERLTG
GRYVDVNIKRDEASRFGMNIADVQSVIASAVGGENIGETVEGLQRFPINVRYPREIRDSL
EQLRSLPIVTERGARLVLSDVADIRITDGPPMLRSENARLSGWVYVDIRGRDLRSAVQDM
QRVVTKEVKLPPGYAVSWSGQFEFLERATAKLKVVVPFTLLIIFVLLYLTFKRFDEALLI
MAALPFALVGGIWLLYLLSYNLSVAGAVGFIALAGVSAEFGVIMLLYLKHAWDERVDEGK
TSTADLLDAIREGAVLRVRPKAMTVAVILAGLFPIMWGTGTGSEVMQRIAAPMVGGMITA
PLLSMFVIPAAYLLMRRPRKASRWTLGRSRRAAV