Protein Info for GFF4048 in Variovorax sp. SCN45

Annotation: Cobalt/zinc/cadmium efflux RND transporter, outer membrane protein CzcC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 PF02321: OEP" amino acids 16 to 151 (136 residues), 66.6 bits, see alignment E=1.3e-22 amino acids 173 to 349 (177 residues), 92.2 bits, see alignment E=1.8e-30

Best Hits

KEGG orthology group: None (inferred from 51% identity to tbd:Tbd_1329)

MetaCyc: 42% identical to cobalt-zinc-cadmium resistance protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (362 amino acids)

>GFF4048 Cobalt/zinc/cadmium efflux RND transporter, outer membrane protein CzcC (Variovorax sp. SCN45)
MEGARVQAGVFQNPTLSVEVEDVRRDTRTTTVLLSQPFELGGKRGARIEAAERAIDVARA
QLETKYADIRANVTAAFFATLISQDRVRLAQASLELARTGSETAGKRVTAGKVSPVEETK
AKVAEANVRLELVQARGELQTNLYQLRALTGPTVVFDAVDGNALQIPKPQAQETIEDRIT
SAPSMRQARLEVKRYGALSELEKAKRIPDITLNAGTMRSREVGRSQAVVGISVPLPIFDT
NRGNITEALRRQDKAEEDARALELRLRADVGGARQRYVTTLAEVEALQSDILPGAQTAFD
AATKGFELGKFSYLDALDAQRTLLQARSQYLRSLSELHRSITDLDRLLGGPAAASGSPVS
NP